Document Detail

Epithelial sodium channels in the adult lung--important modulators of pulmonary health and disease.
MedLine Citation:
PMID:  18269193     Owner:  NLM     Status:  MEDLINE    
Absorption of excess fluid from the airways and alveolar lumen requires active vectorial transepithelial transport of sodium ions (Na+) by alveolar type II and possibly type I cells. The rate-limiting step in this process is the activity of the heterotrimeric apical membrane epithelial Na+ channel (ENaC). Pharmacologic inhibitors and genetic manipulations that disrupt Na+ transport result in fluid accumulation within the lung and failure of gas exchange. The importance of Na+ transport in the lung is also demonstrated in conditions such as ARDS, where abnormal absorption of Na+ contributes to the pathophysiology of pulmonary disease. ENaC expression and function is influenced by diverse factors, such as oxygen tension, glucocorticoids, and cytoskeletal proteins. In addition, ENaC dysfunction has been shown to be induced by purinergic nucleotide activation of P2Y receptors (in paramyxoviral bronchiolitis) and reactive species (in acute lung injury). Finally, beta-adrenergic agonists have been shown experimentally to reverse defects in ENaC function, and improve hypoxemia and pulmonary edema, and may provide a novel therapeutic modality for ARDS, although some viral lung pathogens appear to induce insensitivity to their actions.
Ian C Davis; Sadis Matalon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  618     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2007  
Date Detail:
Created Date:  2008-02-13     Completed Date:  2008-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-40     Citation Subset:  IM    
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
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MeSH Terms
Adrenergic beta-Agonists / therapeutic use
Epithelial Sodium Channel / physiology*
Lung / metabolism*,  physiopathology
Lung Diseases / drug therapy,  etiology*
Risk Factors
Sodium / metabolism
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Epithelial Sodium Channel; 7440-23-5/Sodium

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