Document Detail


Epithelial ovarian cancer treated by platinum or platinum analogue with cyclophosphamide: experience in Ramathibodi Hospital.
MedLine Citation:
PMID:  9470316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study presented the outcome of 92 EOC patients treated by platinum or platinum analogue with cyclophosphamide from January 1, 1993 to December 31, 1995. There were 77 evaluable patients. The follow-up ranged from 4-42 months (median 14 months). The over all 3-year survival was 64 per cent and the median progression-free interval was 16 months for the whole group. There was no significant difference in survival between patients who received cisplatin and those who received carboplatin (P = 0.093). Patients who underwent optimal debulking surgery had significantly longer progression-free interval (P = 0.001) than those who had sub-optimal surgery. Fifty four per cent of patients with clear cell carcinoma died of the disease. Patients who received cisplatin had a drop out rate while on therapy more often (24% vs 5.3%) than that of carboplatin. Toxicities from chemotherapy were moderate but manageable.
Authors:
V Linasmita; S Wilailak; S Srisupundit; S Tangtrakul; S Bullangpoti; N Israngura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  81     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-12     Completed Date:  1998-03-12     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  10-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy*,  mortality,  surgery
Adult
Aged
Antineoplastic Agents / administration & dosage
Antineoplastic Agents, Alkylating / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carboplatin / administration & dosage
Chemotherapy, Adjuvant
Cisplatin / administration & dosage
Cyclophosphamide / administration & dosage
Female
Humans
Middle Aged
Neoplasms, Glandular and Epithelial / drug therapy*,  mortality,  surgery
Ovarian Neoplasms / drug therapy*,  mortality,  surgery
Survival Analysis
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Antineoplastic Agents, Alkylating; 15663-27-1/Cisplatin; 41575-94-4/Carboplatin; 50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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