| Epithelial ovarian cancer treated by platinum or platinum analogue with cyclophosphamide: experience in Ramathibodi Hospital. | |
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MedLine Citation:
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PMID: 9470316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study presented the outcome of 92 EOC patients treated by platinum or platinum analogue with cyclophosphamide from January 1, 1993 to December 31, 1995. There were 77 evaluable patients. The follow-up ranged from 4-42 months (median 14 months). The over all 3-year survival was 64 per cent and the median progression-free interval was 16 months for the whole group. There was no significant difference in survival between patients who received cisplatin and those who received carboplatin (P = 0.093). Patients who underwent optimal debulking surgery had significantly longer progression-free interval (P = 0.001) than those who had sub-optimal surgery. Fifty four per cent of patients with clear cell carcinoma died of the disease. Patients who received cisplatin had a drop out rate while on therapy more often (24% vs 5.3%) than that of carboplatin. Toxicities from chemotherapy were moderate but manageable. |
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Authors:
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V Linasmita; S Wilailak; S Srisupundit; S Tangtrakul; S Bullangpoti; N Israngura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 81 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-03-12 Completed Date: 1998-03-12 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: THAILAND |
Other Details:
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Languages: eng Pagination: 10-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy*,
mortality,
surgery Adult Aged Antineoplastic Agents / administration & dosage Antineoplastic Agents, Alkylating / administration & dosage Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Carboplatin / administration & dosage Chemotherapy, Adjuvant Cisplatin / administration & dosage Cyclophosphamide / administration & dosage Female Humans Middle Aged Neoplasms, Glandular and Epithelial / drug therapy*, mortality, surgery Ovarian Neoplasms / drug therapy*, mortality, surgery Survival Analysis |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Antineoplastic Agents, Alkylating; 15663-27-1/Cisplatin; 41575-94-4/Carboplatin; 50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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