Document Detail


Epithelial-myoepithelial carcinoma of the salivary glands. A study of 22 cases.
MedLine Citation:
PMID:  8322454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-two cases of epithelial-myoepithelial carcinoma of major and minor salivary glands were studied retrospectively to define the clinico-pathological profile and to assess the value of DNA ploidy as a prognostic tool. Fifty-nine percent of the cases occurred in the major salivary glands, the patients being mostly females in their 5th to 8th decades. The clinical course was characterized by a high number of recurrences (in 50% of cases). Death due to the neoplastic disease was found in 40% of the patients. The only morphological feature found to be correlated to prognosis was the presence of nuclear atypia in more than 20% of the tumour cells. In 18 cases, cytophotometric DNA analysis was performed; 15 cases had a diploid DNA histogram and 3 an aneuploid one. All the cases that were DNA aneuploid were of the solid, predominantly clear-cell type and were associated with fatal outcome.
Authors:
I Fonseca; J Soares
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histopathology     Volume:  422     ISSN:  0174-7398     ISO Abbreviation:  Virchows Arch A Pathol Anat Histopathol     Publication Date:  1993  
Date Detail:
Created Date:  1993-08-03     Completed Date:  1993-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302198     Medline TA:  Virchows Arch A Pathol Anat Histopathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  389-96     Citation Subset:  IM    
Affiliation:
Serviço de Patologia Morfológica, Instituto Português de Oncologia de Francisco Gentil, Lisboa.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carcinoma / genetics,  pathology*
DNA, Neoplasm / genetics*
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Ploidies
Prognosis
Retrospective Studies
Salivary Gland Neoplasms / genetics,  pathology*
Chemical
Reg. No./Substance:
0/DNA, Neoplasm

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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