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Epithelial-mesenchymal transition in pulmonary carcinosarcoma: case report and literature review.
MedLine Citation:
PMID:  22229046     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Pulmonary carcinosarcoma is a rare and aggressive neoplasm that has both epithelial and mesenchymal components. We report on a 63-year-old woman who was found to have a right upper-lobe pulmonary carcinosarcoma with metastases to the liver and gastric fundus. There are currently no published guidelines on the treatment of pulmonary sarcomatoid carcinomas. However, with our expanding knowledge of cancer metastasis, cases of carcinosarcoma illustrate our current understanding of epithelial-mesenchymal transition in action. Here, we discuss the development and treatment of these biphasic tumors and the possible role of epithelial-mesenchymal transition.
Authors:
Vibha T Thomas; Stacy Hinson; Kartik Konduri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic advances in medical oncology     Volume:  4     ISSN:  1758-8359     ISO Abbreviation:  Ther Adv Med Oncol     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-09     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101510808     Medline TA:  Ther Adv Med Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  31-7     Citation Subset:  -    
Affiliation:
Rocky Mountain Cancer Centers, Medical Oncology, 22 W. Dry Creek Cir Littleton, CO 80120, USA.
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