Document Detail

Epithelial-mesenchymal transition during trophoblast differentiation.
MedLine Citation:
PMID:  9124037     Owner:  NLM     Status:  MEDLINE    
Embryo implantation in higher primates is mediated by trophoblast: in the earliest phases by syncytiotrophoblast, then by both cytotrophoblast and syncytiotrophoblast. In the course of placentation three main trophoblast populations can be identified: cytotrophoblast stem cells and two differentiated derivative cell types: the syncytiotrophoblast and the extravillous cytotrophoblast. The syncytiotrophoblast remains mainly epithelial while the extravillous cytotrophoblast undergoes an epithelial-mesenchymal transition (EMT), initially forming multilayered cell columns and then, in human, infiltrating deeply the maternal decidual stroma and blood vessels. Finally, some infiltrating cells differentiate further to become giant cells of the placental bed and myometrium. During the course of these events the extravillous cytotrophoblast acquires a distinct phenotype, losing some typical epithelial components (e.g. E-cadherin, integrin alpha 6 beta 4), but retaining others (e.g. cytokeratins). The signals that trigger this EMT are not well understood but its realisation is of critical importance for pregnancy success.
L Vićovac; J D Aplin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta anatomica     Volume:  156     ISSN:  0001-5180     ISO Abbreviation:  Acta Anat (Basel)     Publication Date:  1996  
Date Detail:
Created Date:  1997-04-24     Completed Date:  1997-04-24     Revised Date:  2007-07-02    
Medline Journal Info:
Nlm Unique ID:  0370272     Medline TA:  Acta Anat (Basel)     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  202-16     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, School of Biological Sciences, University of Manchester, UK.
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MeSH Terms
Cell Adhesion Molecules
Cell Differentiation / physiology*
Embryo Implantation / physiology*
Epithelium / physiology
Mesoderm / physiology*
Pregnancy Trimester, First
Trophoblasts / physiology*
Reg. No./Substance:
0/Cell Adhesion Molecules

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