Document Detail

Epithelial membrane antigen expression by the perineurial cell: further studies of peripheral nerve lesions.
MedLine Citation:
PMID:  2759555     Owner:  NLM     Status:  MEDLINE    
We have previously shown that a range of anti-epithelial membrane antigen monoclonal antibodies show immunoreactivity with the perineurial fibroblast, both in normal nerves and within a range of common peripheral nerve tumours. We have extended these observations by studying a further collection of peripheral nerve lesions, including some which have previously been thought to have an origin from the perineurial cell. The results provide further evidence that these antibodies reliably stain perineurial cells and that in conjunction with antisera to S-100 protein and neurofilaments, the relative contributions of the perineurial fibroblast, Schwann cell and neurone can be assessed within a nerve-related tumour/lesion. The perineurial fibroblast is an important component of some peripheral nerve lesions.
J M Theaker; C D Fletcher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  14     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-08     Completed Date:  1989-09-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  581-92     Citation Subset:  IM    
Department of Pathology, Southampton General Hospital, UK.
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MeSH Terms
Fibroblasts / metabolism*,  pathology
Ganglioneuroma / metabolism*,  pathology
Membrane Glycoproteins / metabolism*
Neurofibroma / metabolism*,  pathology
Peripheral Nervous System Neoplasms / metabolism*,  pathology
S100 Proteins / metabolism*
Reg. No./Substance:
0/Membrane Glycoproteins; 0/Mucin-1; 0/S100 Proteins

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