Document Detail

Epithelial markers in synovial sarcoma. An immunohistochemical study on paraffin embedded tissues.
MedLine Citation:
PMID:  2474888     Owner:  NLM     Status:  MEDLINE    
Immunohistochemical studies on synovial sarcomas have proved the potentiality of these neoplasm for epithelial and mesenchymal differentiation and antibodies detecting epithelial cells have been found to be helpful in determining the histological types. In this study different epithelial markers directed against various cytokeratins, HMFG-2 and EMA were investigated on paraffin embedded tissues of 13 cases of synovial sarcomas, with regard to their reliability in unmasking the epithelial components demonstrable in this type of neoplasm. The results lead to three conclusions: firstly, synovial sarcomas possess the capacity for generating different epithelial cell types with uncommon compositions of intermediate filaments as well as of membrane proteins, secondly, these features may be expressed in a heterogenous pattern even within the same tumour and finally, the use of wide range anti-cytokeratin antibodies covering the spectrum of basic as well as acidic type proteins seems to be necessary for the detection of all epithelial components demonstrable in synovial sarcomas.
F Wrba; H Fertl; G Amann; E Tell; R Krepler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histopathology     Volume:  415     ISSN:  0174-7398     ISO Abbreviation:  Virchows Arch A Pathol Anat Histopathol     Publication Date:  1989  
Date Detail:
Created Date:  1989-09-15     Completed Date:  1989-09-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8302198     Medline TA:  Virchows Arch A Pathol Anat Histopathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  253-8     Citation Subset:  IM    
Institut für Pathologische Anatomie der Universität Wien, Vienna, Austria.
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MeSH Terms
Antibodies / metabolism
Breast Neoplasms / analysis,  metabolism,  pathology
Epithelium / analysis,  metabolism,  pathology
Gallbladder Neoplasms / analysis,  metabolism,  pathology
Keratins / immunology
Membrane Glycoproteins / immunology*
Sarcoma, Synovial / analysis,  metabolism*,  pathology
Skin Neoplasms / analysis,  metabolism,  pathology
Stomach Neoplasms / analysis,  metabolism,  pathology
Synovial Membrane / analysis
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/Antibodies; 0/Membrane Glycoproteins; 0/Mucin-1; 0/Tumor Markers, Biological; 68238-35-7/Keratins

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