Document Detail


Epithelial machines of morphogenesis and their potential application in organ assembly and tissue engineering.
MedLine Citation:
PMID:  22854913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sheets of embryonic epithelial cells coordinate their efforts to create diverse tissue structures such as pits, grooves, tubes, and capsules that lead to organ formation. Such cells can use a number of cell behaviors including contractility, proliferation, and directed movement to create these structures. By contrast, tissue engineers and researchers in regenerative medicine seeking to produce organs for repair or replacement therapy can combine cells with synthetic polymeric scaffolds. Tissue engineers try to achieve these goals by shaping scaffold geometry in such a way that cells embedded within these scaffold self-assemble to form a tissue, for instance aligning to synthetic fibers, and assembling native extracellular matrix to form the desired tissue-like structure. Although self-assembly is a dominant process that guides tissue assembly both within the embryo and within artificial tissue constructs, we know little about these critical processes. Here, we compare and contrast strategies of tissue assembly used by embryos to those used by engineers during epithelial morphogenesis and highlight opportunities for future applications of developmental biology in the field of tissue engineering.
Authors:
Sagar D Joshi; Lance A Davidson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-08-02
Journal Detail:
Title:  Biomechanics and modeling in mechanobiology     Volume:  11     ISSN:  1617-7940     ISO Abbreviation:  Biomech Model Mechanobiol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-18     Completed Date:  2013-03-21     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101135325     Medline TA:  Biomech Model Mechanobiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1109-21     Citation Subset:  IM; S    
Affiliation:
Department of Bioengineering, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15213, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Epithelial Cells / physiology*,  transplantation*
Epithelium / embryology*,  growth & development*
Humans
Morphogenesis / physiology
Organogenesis / physiology*
Tissue Engineering / methods*,  trends*
Grant Support
ID/Acronym/Agency:
ES019259/ES/NIEHS NIH HHS; HD044750/HD/NICHD NIH HHS; R01 HD044750/HD/NICHD NIH HHS; R21 ES019259/ES/NIEHS NIH HHS
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