Document Detail

Epithelial junctions and Rho family GTPases: the zonular signalosome.
MedLine Citation:
PMID:  25483301     Owner:  NLM     Status:  Publisher    
ABSTRACT The establishment and maintenance of epithelial cell-cell junctions is crucially important to regulate adhesion, apico-basal polarity and motility of epithelial cells, and ultimately controls the architecture and physiology of epithelial organs. Junctions are supported, shaped and regulated by cytoskeletal filaments, whose dynamic organization and contractility are finely tuned by GTPases of the Rho family, primarily RhoA, Rac1 and Cdc42. Recent research has identified new molecular mechanisms underlying the cross-talk between these GTPases and epithelial junctions. Here we briefly summarize the current knowledge about the organization, molecular evolution and cytoskeletal anchoring of cell-cell junctions, and we comment on the most recent advances in the characterization of the interactions between Rho GTPases and junctional proteins, and its consequences with regards to junction assembly and regulation and cell behaviour in vertebrate model systems. The concept of "zonular signalosome" is proposed, which highlights the close functional relationship between proteins of zonular junctions (zonulae occludentes and adhaerentes) and the control of cytoskeletal organization and signalling through Rho GTPases, transcription factors, and their effectors.
Sandra Citi; Diego Guerrera; Domenica Spadaro; Jimit Shah
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-11
Journal Detail:
Title:  Small GTPases     Volume:  -     ISSN:  2154-1256     ISO Abbreviation:  Small GTPases     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-8     Completed Date:  -     Revised Date:  2014-12-9    
Medline Journal Info:
Nlm Unique ID:  101530974     Medline TA:  Small GTPases     Country:  -    
Other Details:
Languages:  ENG     Pagination:  0     Citation Subset:  -    
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