Document Detail

Epithelial dendritic cells in pathological human oral tissues.
MedLine Citation:
PMID:  2473203     Owner:  NLM     Status:  MEDLINE    
Epithelial dendritic cells (EDC) were examined in human oral tissues with non-specific keratosis, lichen planus and squamous cell carcinoma. Acetone-fixed frozen sections were stained using an indirect immunoperoxidase technique and monoclonal antibodies to the human CD1 thymocyte (OKT6) and HLA-DR antigens. Significantly more T6+ and DR+ EDC were present in lichen planus tissues than normal controls, tissues with non-specific keratosis and the epithelial overlying/adjacent to squamous cell carcinomas, the latter tissues having comparable numbers of both T6+ and DR+ EDC. By contrast, significantly fewer T6+ EDC and significantly more DR+ cells were present in the invasive epithelium of squamous cell carcinomas than the overlying/adjacent epithelium of carcinomas, the non-specific keratosis group and the normal tissues. 23-60% of pathological tissues had either focal or general DR+ reactivity in keratinocytes, but there was no correlation between the density of T6+ or DR+ EDC and the keratinocyte DR status of the tissues. The results suggest that immunological enhancement occurs in lichen planus and possibly immunological impairment may characterize invasive squamous cell carcinoma.
A Pitigala-Arachchi; I J Crane; C Scully; S S Prime
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  18     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-08-14     Completed Date:  1989-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  D; IM    
Department of Oral Medicine, Surgery & Pathology, University of Bristol, England.
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MeSH Terms
Carcinoma, Squamous Cell / pathology
Dendritic Cells / immunology,  pathology*
Epidermis / immunology,  pathology
Epithelium / pathology
HLA-DR Antigens / analysis*
Immunoenzyme Techniques
Langerhans Cells / pathology
Leukoplakia, Oral / pathology
Lichen Planus / pathology
Mouth Diseases / pathology*
Mouth Mucosa / immunology,  pathology*
Mouth Neoplasms / pathology*
Reg. No./Substance:
0/HLA-DR Antigens; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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