Document Detail

Epithelial cells and airway diseases.
MedLine Citation:
PMID:  21682746     Owner:  NLM     Status:  In-Data-Review    
Summary:  The airway epithelial cell is the initial cell type impacted both by inhaled environmental factors, such as pathogens, allergens, and pollutants, and inhaled medications for airway diseases. As such, epithelial cells are now recognized to play a central role in the regulation of airway inflammatory status, structure, and function in normal and diseased airways. This article reviews our current knowledge regarding the roles of the epithelial cell in airway inflammation and host defense. The interactions of inhaled environmental factors and pathogens with epithelial cells are also discussed, with an emphasis on epithelial innate immune responses and contributions of epithelial cells to immune regulation. Recent evidence suggesting that epithelial cells play an active role in inducing several of the structural changes, collectively referred to airway remodeling, seen in the airways of asthmatic subjects is reviewed. Finally, the concept that the epithelium is a major target for the actions of a number of classes of inhaled medications is discussed, as are the potential mechanisms by which selected drugs may alter epithelial function.
David Proud; Richard Leigh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunological reviews     Volume:  242     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  186-204     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Department of Physiology and Pharmacology, University of Calgary Faculty of Medicine, Calgary, AB, Canada. Department of Medicine, University of Calgary Faculty of Medicine, Calgary, AB, Canada.
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