| Epithelial cell kinetics of the gastric mucosa during Helicobacter pylori infection. | |
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MedLine Citation:
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PMID: 17521356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Helicobacter pylori is an important pathogen in major gastroduodenal diseases, including inflammation with ulceration and gastric malignancies. Alterations in H. pylori associated cell turnover in gastric epithelial cells are examined in relation to inflammatory activity, bacteria load and cytokines which may improve knowledge concerning the outcome of gastric diseases caused by H. pylori. Antral biopsies from 42 dyspeptic patients including 27 H. pylori-positive and 15 H. pylori-negative patients were tested for apoptotic activity by the TUNEL assay, and immuno-histochemically for p53 and the proliferative marker Ki-67. H. pylori infection, bacteria load and inflammatory activity were associated with increased cell turnover as judged by enhanced activities of TUNEL, p53 and Ki-67. Only p53 was significantly correlated to IFN-gamma, IL-8 and IL-10. The H. pylori-positive state was furthermore accompanied by varying degrees of altered distribution pattern of the markers studied, with occasional presence of apoptosis in the deeper pit zones, upward extension of Ki-67 and to a lesser degree of p53. Given a similar pattern of change in proliferation and apoptosis in some neoplastic lesions in other parts of the gastrointestinal tract, such studies in cell turnover may provide insights valuable in the investigations of potential precursors of gastric malignancies. |
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Authors:
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Susanne Holck; Inger L Holm; Peter P Holck; Marianne Pedersen; Annette Nørgaard; Svend Norn; Henrik Permin; Leif P Andersen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-22 |
Journal Detail:
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Title: FEMS immunology and medical microbiology Volume: 50 ISSN: 0928-8244 ISO Abbreviation: FEMS Immunol. Med. Microbiol. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-14 Completed Date: 2007-08-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9315554 Medline TA: FEMS Immunol Med Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 206-12 Citation Subset: IM |
Affiliation:
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Department of Pathology, Copenhagen University Hospital, Hvidovre, Denmark. susanne.holck@hvh.regionh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis Biopsy Cell Proliferation Epithelial Cells / pathology* Female Gastric Mucosa / pathology* Helicobacter Infections / microbiology, pathology* Helicobacter pylori Humans Immunohistochemistry In Situ Nick-End Labeling Interferon-gamma / biosynthesis Interleukin-10 / biosynthesis Interleukin-8 / biosynthesis Ki-67 Antigen / analysis Kinetics Male Pyloric Antrum / pathology* Tumor Suppressor Protein p53 / analysis |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-8; 0/Ki-67 Antigen; 0/Tumor Suppressor Protein p53; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma |
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