Document Detail

Epithelial stem/progenitor cells in the embryonic mouse submandibular gland.
MedLine Citation:
PMID:  20428013     Owner:  NLM     Status:  MEDLINE    
Salivary gland organogenesis involves the specification, maintenance, lineage commitment, and differentiation of epithelial stem/progenitor cells. Identifying how stem/progenitor cells are directed along a series of cell fate decisions to form a functional salivary gland will be necessary for future stem cell regenerative therapy. The identification of stem/progenitor cells within the salivary gland has focused on their role in postnatal glands and little is known about them in embryonic glands. Here, we have reviewed the information available for other developing organ systems and used it to determine whether similar cell populations exist in the mouse submandibular gland. Additionally, using growth factors that influence salivary gland epithelial morphogenesis during development, we have taken a simple experimental approach asking whether any of these growth factors influence early developmental lineages within the salivary epithelium on a transcriptional level. These preliminary findings show that salivary epithelial stem/progenitor populations exist within the gland, and that growth factors that are reported to control epithelial morphogenesis may also impact cell fate decisions. Further investigation of the signaling networks that influence stem/progenitor cell behavior will allow us to hypothesize how we might induce autologous stem cells to regenerate damaged salivary tissue in a therapeutic context.
Isabelle M A Lombaert; Matthew P Hoffman
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-04-20
Journal Detail:
Title:  Frontiers of oral biology     Volume:  14     ISSN:  1420-2433     ISO Abbreviation:  Front Oral Biol     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-29     Completed Date:  2010-08-18     Revised Date:  2013-03-28    
Medline Journal Info:
Nlm Unique ID:  9812095     Medline TA:  Front Oral Biol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  90-106     Citation Subset:  D; IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda, MD 20892, USA.
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MeSH Terms
Cell Lineage / physiology
Epithelial Cells / physiology*
Intercellular Signaling Peptides and Proteins / physiology
Morphogenesis / physiology
Organogenesis / physiology
Stem Cells / physiology*
Submandibular Gland / cytology*,  embryology
Grant Support
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins

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