Document Detail


Epithelia: lymphocyte interactions in the gut.
MedLine Citation:
PMID:  17291293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mucosal immune system is governed by a unique set of rules and regulations. The local microenvironment dictates the necessity for these differences. The intestinal epithelial cell (IEC) sits at the interface between an antigen-rich lumen and a lymphocyte-rich lamina propria (LP). The cross talk that occurs between these compartments serves to maintain intestinal homeostasis. IECs have the capacity to talk to LP lymphocytes, activating populations of unique regulatory T cells. These cells have the capacity to talk back to the epithelium, influencing epithelial cell growth and differentiation. This review looks at this cross talk and places it in the context of mucosal immunoregulation.
Authors:
Stephanie Dahan; Franziska Roth-Walter; Paul Arnaboldi; Shradha Agarwal; Lloyd Mayer
Related Documents :
11487533 - Ccr9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from c...
19324043 - Prominin-1/cd133 marks stem cells and early progenitors in mouse small intestine.
7886653 - Reduction in leukotriene b4 generation by bronchoalveolar lavage cells in asthma.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  215     ISSN:  0105-2896     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-12     Completed Date:  2007-03-29     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  243-53     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antigen-Presenting Cells / immunology,  metabolism
Cell Communication / immunology*
Epithelial Cells / immunology*,  metabolism
Humans
Immunity, Mucosal*
Intestinal Mucosa / cytology,  immunology*
Lymphocyte Activation / immunology
Receptor Cross-Talk / immunology*
T-Lymphocytes / immunology*,  metabolism
Grant Support
ID/Acronym/Agency:
R01 AI023504/AI/NIAID NIH HHS; R01 AI023504-11/AI/NIAID NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Generation of gut-homing T cells and their localization to the small intestinal mucosa.
Next Document:  Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senes...