Document Detail

Epithelia: lymphocyte interactions in the gut.
MedLine Citation:
PMID:  17291293     Owner:  NLM     Status:  MEDLINE    
The mucosal immune system is governed by a unique set of rules and regulations. The local microenvironment dictates the necessity for these differences. The intestinal epithelial cell (IEC) sits at the interface between an antigen-rich lumen and a lymphocyte-rich lamina propria (LP). The cross talk that occurs between these compartments serves to maintain intestinal homeostasis. IECs have the capacity to talk to LP lymphocytes, activating populations of unique regulatory T cells. These cells have the capacity to talk back to the epithelium, influencing epithelial cell growth and differentiation. This review looks at this cross talk and places it in the context of mucosal immunoregulation.
Stephanie Dahan; Franziska Roth-Walter; Paul Arnaboldi; Shradha Agarwal; Lloyd Mayer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  215     ISSN:  0105-2896     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-12     Completed Date:  2007-03-29     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  243-53     Citation Subset:  IM    
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MeSH Terms
Antigen-Presenting Cells / immunology,  metabolism
Cell Communication / immunology*
Epithelial Cells / immunology*,  metabolism
Immunity, Mucosal*
Intestinal Mucosa / cytology,  immunology*
Lymphocyte Activation / immunology
Receptor Cross-Talk / immunology*
T-Lymphocytes / immunology*,  metabolism
Grant Support

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