| Epistatic effect between ACACA and FABP2 gene on abdominal fat traits in broilers. | |
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MedLine Citation:
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PMID: 20816383 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Epistasis is generally defined as the interaction between two or more genes or their mRNA or protein products to influence a single trait. Experimental evidence suggested that epistasis could be important in the determination of the genetic architecture of complex traits in domestic animals. Acetyl-coenzyme A carboxylase alpha (ACACA) and fatty acid binding protein 2 (FABP2) are both key factors of lipogenesis and transport. They may play a crucial role in the weight variability of abdominal adipose tissue in the growing chicken. In this study, the polymorphisms of c.2292G>A in ACACA and c.-561A>C in FABP2 were detected among individuals from two broiler lines which were divergently selected for abdominal fat content. Epistasis between the two SNPs on abdominal fat weight (AFW) and abdominal fat percentage (AFP) was analyzed. The additive x additive epistatic components between these two SNPs were found significant or suggestively significant on both AFW and AFP in lean lines of the 9th and 10th generation; whereas, it was not significantly associated with either AFW or AFP in fat lines. At the same time, there were not any other significant epistatic components found in both generations or in both lines. Significant epistatic effects between these two SNPs found only in the lean lines could partly be due to the fact that the abdominal fat traits in these two experimental lines have been greatly modified by strong artificial selection. The results suggested that the epistasis mode may be different between the lean and fat chicken lines. Our results could be helpful in further understanding the genetic interaction between candidate genes contributing to phenotypic variation of abdominal fat content in broilers. |
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Authors:
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Guo Hu; Shouzhi Wang; Jianwei Tian; Lili Chu; Hui Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of genetics and genomics = Yi chuan xue bao Volume: 37 ISSN: 1673-8527 ISO Abbreviation: J Genet Genomics Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101304616 Medline TA: J Genet Genomics Country: China |
Other Details:
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Languages: eng Pagination: 505-12 Citation Subset: IM |
Affiliation:
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College of Animal Science and Technology, Northeast Agricultural University, Harbin, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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