| Epistasis contributes to the genetic buffering of plasma HDL cholesterol in mice. | |
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MedLine Citation:
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PMID: 20858711 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stressful environmental factors, such as a high-fat diet, can induce responses in the expression of genes that act to maintain physiological homeostasis. We observed variation in plasma concentrations of high-density lipoprotein (HDL) cholesterol across inbred mouse strains in response to high dietary fat intake. Several strains, including C57BL/6J, have stable levels of plasma HDL independent of diet, whereas other strains, including DBA2/J, show marked changes in plasma HDL. To explore this phenomenon further, we used publicly available data from a C57BL/6J × DBA/2J intercross to identify genetic factors that associate with HDL under high-fat diet conditions. Our analysis identified an epistatic interaction that plays a role in the buffering of HDL levels in C57BL/6J mice, and we have identified Arl4d as a candidate gene that mediates this effect. Structural modeling further elucidates the interaction of genetic factors that contribute to the robustness of HDL in response to high-fat diet in the C57BL/6J strain. |
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Authors:
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Renhua H Li; Gary A Churchill |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-21 |
Journal Detail:
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Title: Physiological genomics Volume: 42A ISSN: 1531-2267 ISO Abbreviation: Physiol. Genomics Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-30 Completed Date: 2011-02-28 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 9815683 Medline TA: Physiol Genomics Country: United States |
Other Details:
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Languages: eng Pagination: 228-34 Citation Subset: IM |
Affiliation:
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The Jackson Laboratory, Bar Harbor, Maine, USA. lir3@niddk.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ADP-Ribosylation Factors
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genetics,
metabolism* Animals Cholesterol, HDL / blood* Crosses, Genetic Dietary Fats / metabolism* Epistasis, Genetic* Female Lipoproteins, HDL / genetics* Male Mice Mice, Inbred C57BL Mice, Inbred DBA Species Specificity |
| Grant Support | |
ID/Acronym/Agency:
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GM-070683/GM/NIGMS NIH HHS; GM-076468/GM/NIGMS NIH HHS; R01 GM070683-07/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Dietary Fats; 0/Lipoproteins, HDL; EC 3.6.5.2/ADP-Ribosylation Factors; EC 3.6.5.2/Arl4D protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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