Document Detail

Epistasis between deleterious mutations and the evolution of recombination.
MedLine Citation:
PMID:  17337087     Owner:  NLM     Status:  MEDLINE    
Epistasis and the evolution of recombination are closely intertwined: epistasis generates linkage disequilibria (i.e. statistical associations between alleles), whereas recombination breaks them up. The mutational deterministic hypothesis (MDH) states that high recombination rates are maintained because the breaking up of linkage disequilibria generated by negative epistasis enables more efficient purging of deleterious mutations. However, recent theoretical and experimental work challenges the MDH. Experimental evidence suggests that negative epistasis, required by the MDH, is relatively uncommon. On the theoretical side, population genetic models suggest that, compared with the combined effects of drift and selection, epistasis generates a negligible amount of linkage disequilibria. Here, we assess these criticisms and discuss to what extent they invalidate the MDH as an explanation for the evolution of recombination.
Roger D Kouyos; Olin K Silander; Sebastian Bonhoeffer
Related Documents :
11981817 - Alternative end joining during switch recombination in patients with ataxia-telangiecta...
6363387 - Suppression of escherichia coli recf mutations by reca-linked srfa mutations.
6234687 - The new recombinant haplotypes r19 and r20 in rt1, the mhc of the rat.
11114897 - Hin recombinase mutants functionally disrupted in interactions with fis.
10703617 - Identification of the novel allele hla-b*1545: assessment of alloreactivity in case of ...
22248077 - Esr1, hk3 and brsk1 gene variants are associated with both age at natural menopause and...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-03-06
Journal Detail:
Title:  Trends in ecology & evolution     Volume:  22     ISSN:  0169-5347     ISO Abbreviation:  Trends Ecol. Evol. (Amst.)     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-09-13     Revised Date:  2011-05-03    
Medline Journal Info:
Nlm Unique ID:  8805125     Medline TA:  Trends Ecol Evol     Country:  England    
Other Details:
Languages:  eng     Pagination:  308-15     Citation Subset:  IM    
Institute of Integrative Biology, ETH Zürich Universitätsstrasse 16, 8092, Zürich, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Evolution*
Epistasis, Genetic*
Models, Genetic
Mutation, Missense*
Recombination, Genetic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A novel triplet regimen with paclitaxel, carboplatin and gemcitabine (PACCAGE) as induction chemothe...
Next Document:  Effects of the pig renal epithelial cell line LLC-PK1 and its conditioned medium on the phenotype of...