Document Detail


Epistasis between deleterious mutations and the evolution of recombination.
MedLine Citation:
PMID:  17337087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epistasis and the evolution of recombination are closely intertwined: epistasis generates linkage disequilibria (i.e. statistical associations between alleles), whereas recombination breaks them up. The mutational deterministic hypothesis (MDH) states that high recombination rates are maintained because the breaking up of linkage disequilibria generated by negative epistasis enables more efficient purging of deleterious mutations. However, recent theoretical and experimental work challenges the MDH. Experimental evidence suggests that negative epistasis, required by the MDH, is relatively uncommon. On the theoretical side, population genetic models suggest that, compared with the combined effects of drift and selection, epistasis generates a negligible amount of linkage disequilibria. Here, we assess these criticisms and discuss to what extent they invalidate the MDH as an explanation for the evolution of recombination.
Authors:
Roger D Kouyos; Olin K Silander; Sebastian Bonhoeffer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-03-06
Journal Detail:
Title:  Trends in ecology & evolution     Volume:  22     ISSN:  0169-5347     ISO Abbreviation:  Trends Ecol. Evol. (Amst.)     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-09-13     Revised Date:  2011-05-03    
Medline Journal Info:
Nlm Unique ID:  8805125     Medline TA:  Trends Ecol Evol     Country:  England    
Other Details:
Languages:  eng     Pagination:  308-15     Citation Subset:  IM    
Affiliation:
Institute of Integrative Biology, ETH Zürich Universitätsstrasse 16, 8092, Zürich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Biological Evolution*
Epistasis, Genetic*
Models, Genetic
Mutation, Missense*
Recombination, Genetic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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