Document Detail


Episodic hypoxia evokes long-term facilitation of genioglossus muscle activity in neonatal rats.
MedLine Citation:
PMID:  15047768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to determine if episodic hypoxia evokes persistent increases of genioglossus muscle (GG) activity, termed long-term facilitation (LTF), in neonatal rats in vivo. Experiments were performed on anaesthetized, spontaneously breathing, intubated neonatal rats (postnatal days (P) 3-7), divided into three groups. The first group (n= 8) was subjected to three 5-min periods of hypoxia (5% O(2)-95% N(2)) alternating with 5 min periods of room air. The second group (n= 8) was exposed to 15 min of continuous hypoxia. The third (n= 4) group was not exposed to hypoxia and served as a control. GG EMG activity and airflow were recorded before, during and for 60 min after episodic and continuous hypoxic exposure. During hypoxia, GG EMG burst amplitude and tidal volume (V(T)) significantly increased compared to baseline levels (episodic protocol: mean +/-S.E.M; 324 +/- 59% of control and 0.13 +/- 0.007 versus 0.09 +/- 0.005 ml, respectively; continuous protocol: 259 +/- 30% of control and 0.16 +/- 0.005 versus 0.09 +/- 0.007 ml, respectively; P < 0.05). After the episodic protocol, GG EMG burst amplitude transiently returned to baseline; over the next 60 min, burst amplitude progressively increased to levels significantly greater than baseline (238 +/- 40% at 60 min; P < 0.05), without any significant increase in V(T) and respiratory frequency (P> 0.05). After the continuous protocol, there was no lasting increase in GG EMG burst amplitude. We conclude that LTF of upper airway muscles is an adaptive respiratory behaviour present from birth.
Authors:
Leanne C McKay; Wiktor A Janczewski; Jack L Feldman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2004-03-26
Journal Detail:
Title:  The Journal of physiology     Volume:  557     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-11     Completed Date:  2004-12-06     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
Affiliation:
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1763, USA. lmckay@mednet.ucla.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Anoxia / physiopathology*
Electrodes, Implanted
Electromyography
Female
Hypoglossal Nerve / physiology
Male
Rats
Rats, Sprague-Dawley
Tongue / innervation,  physiology*
Grant Support
ID/Acronym/Agency:
HL070029/HL/NHLBI NIH HHS
Comments/Corrections

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