| Episodic conjunctival inflammation after Stevens-Johnson syndrome. | |
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MedLine Citation:
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PMID: 3050689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors studied the histopathologic, ultrastructural, and immunopathologic characteristics of conjunctiva from patients with Stevens-Johnson syndrome (SJS). A small subset of SJS patients with recurrent conjunctival inflammation unassociated with external factors such as lid margin keratinization, sicca syndrome, trichiasis, or entropion was identified. The ultrastructural and immunopathologic characteristics of the conjunctiva from these patients were distinctly different from those of the conjunctiva from SJS patients without recurrent conjunctivitis, and suggested an active, immunologically mediated inflammation. Vasculitis or perivasculitis, immunoreactant deposition in vessel walls, vascular basement membrane disruption, thickening, and reduplication, and a preponderance of helper T-lymphocytes, macrophages, and Langerhans' cells were the notable distinguishing features in those patients with recurrent conjunctival inflammation. This rare clinical syndrome may represent the ocular counterpart to recurrent dermal or oral mucosal erythema multiforme. |
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Authors:
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C S Foster; L P Fong; D Azar; K R Kenyon |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Ophthalmology Volume: 95 ISSN: 0161-6420 ISO Abbreviation: Ophthalmology Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-11-23 Completed Date: 1988-11-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 453-62 Citation Subset: IM |
Affiliation:
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Hilles Immunology Laboratory, Massachusetts Eye and Ear Infirmary, Boston 02114. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biopsy Child Conjunctiva / blood supply, pathology, ultrastructure Conjunctivitis / etiology*, metabolism, pathology Endothelium, Vascular / metabolism, pathology, ultrastructure Female Fluorescent Antibody Technique Humans Immunoenzyme Techniques Immunoglobulin G / metabolism Male Metaplasia Microscopy, Electron Recurrence Stevens-Johnson Syndrome / complications* |
| Grant Support | |
ID/Acronym/Agency:
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EY 03967/EY/NEI NIH HHS; EY 06008/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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