| Epirubicin: Is it like doxorubicin in breast cancer? A clinical review. | |
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MedLine Citation:
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PMID: 22260846 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Anthracyclines are among the most effective chemotherapy treatments available for various types of cancer. The anthracyclines commonly used in treatment of breast cancer are either epirubicin or doxorubicin. Epirubicin is an epimer of doxorubicin with important role in the chemotherapy treatment of both early and metastatic breast cancer. The efficacy of epirubicin is similar to doxorubicin while epirubicin has a different toxicity profile particularly in regard to cardiotoxicity. Epirubicin has been incorporated into most of the anthracycline containing chemotherapy combinations in well-conducted clinical trials involving large numbers of patients. It has also been investigated in studies involving the administration of epirubicin in dose-dense chemotherapy schedules. Short term follow up of dose-dense clinical trials demonstrated safety comparable to that of doxorubicin. This review summarizes published clinical trials investigating epirubicin in the treatment of early and advanced breast cancer. |
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Authors:
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Mustafa Khasraw; Richard Bell; Chau Dang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
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Title: Breast (Edinburgh, Scotland) Volume: - ISSN: 1532-3080 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9213011 Medline TA: Breast Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Andrew Love Cancer Center, Geelong Hospital, Australia; School of Medicine of Deakin University, Geelong VIC 3220, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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