Document Detail

Epinephrine synthesis by rat arteries.
MedLine Citation:
PMID:  2006996     Owner:  NLM     Status:  MEDLINE    
Carotid artery and aorta homogenates synthesized epinephrine (E) from norepinephrine (NE) in the presence of S-adenosylmethionine. Aorta synthesized epinine by the N-methylation of dopamine (DA) about 3 times as well as it synthesized E from NE. In contrast, adrenal homogenates which contain phenylethanolamine N-methyltransferase (PNMT) methylated DA only 1% as well as NE. The PNMT inhibitor SKF 29661 had no significant effect on methylation of NE by aorta but inhibited adrenal PNMT by 88%. N-Methylating activity in arterial homogenates was increased by dexamethasone and following catecholamine depletion by 6-hydroxydopamine (6-OHDA) and reserpine. Nine days after adrenal demedullation blood E levels collected at decapitation were less than 7% of levels found in sham operated controls but artery homogenate E was unchanged. Demedullated rats given 6-OHDA followed by reserpine for 4 days also had unchanged arterial E levels despite arterial NE levels that were less than 15% of controls. We conclude that arteries synthesize E in vitro and appear to synthesize E in vivo using an extraneuronal N-methyltransferase. This enzyme differs from adrenal PNMT in substrate and inhibitor specificity and its activity is enhanced by catecholamine depletion and by glucocorticoid treatment.
B Kennedy; H Elayan; M G Ziegler
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  4     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-04-30     Completed Date:  1991-04-30     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-50     Citation Subset:  IM    
Department of Medicine, University of California San Diego Medical Center 92103.
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MeSH Terms
Aorta / drug effects,  metabolism*
Carotid Arteries / drug effects,  metabolism*
Catecholamines / blood
Epinephrine / biosynthesis*
Rats, Inbred Strains
S-Adenosylmethionine / pharmacology
Grant Support
Reg. No./Substance:
0/Catecholamines; 29908-03-0/S-Adenosylmethionine; 51-43-4/Epinephrine

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