Document Detail

Epinephrine infusion does not enhance net muscle glycogenolysis during prolonged aerobic exercise.
MedLine Citation:
PMID:  8853469     Owner:  NLM     Status:  MEDLINE    
The role of physiological elevations of plasma epinephrine concentration on muscle glycogenolysis during prolonged exercise was investigated. Eight healthy volunteers cycled for 90 min at 65%. VO2max on two occasions; one with an infusion of epinephrine (EPI) and once without (control). Biopsy samples were taken from the vastus lateralis muscle both prior to and following exercise for the analysis of muscle glycogen. EPI infusion significantly elevated venous plasma EPI approximately 2.5-fold over control values throughout exercise (90 min: 5.78 +/- 0.95 vs. 2.35 +/- 0.49 nM). EPI infusion did not significantly alter net glycogenolysis as compared to control (310.0 +/- 30.8 vs. 229.5 +/- 41.1 mmol glucosyl units/kg dry mass). Venous concentrations of plasma FFA and whole blood glycerol were unaffected by EPI infusion. Whole blood glucose was significantly elevated during EPI infusion at 10, 30, 60 and 90 min of exercise compared to control values. Whole blood lactate was elevated to a greater extent during EPI infusion as compared to control at 10, 30, and 60 min of exercise. In conclusion, EPI infusion had no effect on muscle glycogenolysis and appeared to have little effect on adipose tissue lipolysis. The explanation for the elevation of blood lactate is unknown while the elevation in blood glucose suggests that EPI infusion potentiated liver glycogenolysis.
P S Wendling; S J Peters; G J Heigenhauser; L L Spriet
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of applied physiology = Revue canadienne de physiologie appliquée     Volume:  21     ISSN:  1066-7814     ISO Abbreviation:  Can J Appl Physiol     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-12-24     Completed Date:  1996-12-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306274     Medline TA:  Can J Appl Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  271-84     Citation Subset:  IM; S    
Department of Human Biology and Nutritional Sciences, University of Guelph, ON.
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MeSH Terms
Adipose Tissue / drug effects,  metabolism
Adrenergic Agonists / administration & dosage,  blood,  pharmacology*
Blood Glucose / analysis
Epinephrine / administration & dosage,  blood,  pharmacology*
Exercise / physiology*
Exercise Test
Fatty Acids, Nonesterified / blood
Glycerol / blood
Glycogen / analysis,  metabolism*
Infusions, Intravenous
Lactates / blood
Lipid Metabolism
Liver / drug effects,  metabolism
Muscle, Skeletal / drug effects*,  metabolism,  pathology
Reg. No./Substance:
0/Adrenergic Agonists; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Lactates; 51-43-4/Epinephrine; 56-81-5/Glycerol; 9005-79-2/Glycogen

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