| Epinephrine in resuscitation: curse or cure? | |
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MedLine Citation:
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PMID: 20608820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of epinephrine during cardiac arrest has been advocated for decades and forms an integral part of the published guidelines. Its efficacy is supported by animal data, but human trial evidence is lacking. This is partly attributable to disparities in trial methodology. Epinephrine's pharmacologic and physiologic effects include an increase in coronary perfusion pressure that is key to successful resuscitation. One possible explanation for the lack of epinephrine's demonstrated efficacy in human trials of out-of-hospital cardiac arrest is the delay in its administration. A potential solution may be intraosseus epinephrine, which can be administered quicker. More importantly, it is the quality of the basic life support, early and uninterrupted chest compressions, early defibrillation and postresuscitation care that will provide the best chance of neurologically intact survival. |
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Authors:
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Robert R Attaran; Gordon A Ewy |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Future cardiology Volume: 6 ISSN: 1744-8298 ISO Abbreviation: Future Cardiol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101239345 Medline TA: Future Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 473-82 Citation Subset: IM |
Affiliation:
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University of Arizona College of Medicine, Tucson, AZ, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Agonists
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administration & dosage* Animals Cardiopulmonary Resuscitation / methods*, standards Disease Models, Animal Dose-Response Relationship, Drug Epinephrine / administration & dosage* Heart Arrest / drug therapy*, therapy Humans Infusions, Intraosseous |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Agonists; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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