Document Detail


Epinephrine enables Pavlovian fear conditioning under anesthesia.
MedLine Citation:
PMID:  6695173     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats under Pavlovian defensive conditioning (noise paired with shock) while under general anesthesia. Peripheral administration of epinephrine (0.01 to 1.0 milligram per kilogram of body weight) during training resulted in the acquisition of conditioned fear, as shown 10 days later by conditioned suppression of water drinking. Analysis of heart rate and measurement of reflexes during training indicated that epinephrine did not lighten the state of anesthesia. These results indicate that epinephrine enables the learning of conditioned fear in the anesthetized brain.
Authors:
N M Weinberger; P E Gold; D B Sternberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  223     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-03-12     Completed Date:  1984-03-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  605-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General*
Animals
Chloral Hydrate
Conditioning (Psychology) / drug effects*
Epinephrine / pharmacology*
Fear
Male
Pentobarbital
Rats
Rats, Inbred Strains
Reinforcement (Psychology)*
Grant Support
ID/Acronym/Agency:
AL 01642//PHS HHS; MH 12526/MH/NIMH NIH HHS; MH 31144/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
302-17-0/Chloral Hydrate; 51-43-4/Epinephrine; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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