| Epinephrine enables Pavlovian fear conditioning under anesthesia. | |
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MedLine Citation:
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PMID: 6695173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats under Pavlovian defensive conditioning (noise paired with shock) while under general anesthesia. Peripheral administration of epinephrine (0.01 to 1.0 milligram per kilogram of body weight) during training resulted in the acquisition of conditioned fear, as shown 10 days later by conditioned suppression of water drinking. Analysis of heart rate and measurement of reflexes during training indicated that epinephrine did not lighten the state of anesthesia. These results indicate that epinephrine enables the learning of conditioned fear in the anesthetized brain. |
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Authors:
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N M Weinberger; P E Gold; D B Sternberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 223 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-03-12 Completed Date: 1984-03-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 605-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, General* Animals Chloral Hydrate Conditioning (Psychology) / drug effects* Epinephrine / pharmacology* Fear Male Pentobarbital Rats Rats, Inbred Strains Reinforcement (Psychology)* |
| Grant Support | |
ID/Acronym/Agency:
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AL 01642//PHS HHS; MH 12526/MH/NIMH NIH HHS; MH 31144/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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302-17-0/Chloral Hydrate; 51-43-4/Epinephrine; 76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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