| Epinephrine affects hemodynamics of noninnervated normal and all-trans retinoic acid-treated embryonic chick hearts. | |
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MedLine Citation:
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PMID: 15305100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the acute effect of epinephrine on hemodynamics of noninnervated normal and retinoic-acid-treated embryos. DESIGN: Prospective interventional study design. METHODS: A total of 190 stage 15 (50-55 h of incubation) chick embryos were randomly treated with 1 microg all-trans retinoic acid and reincubated. At stage 20 (day 3) and stage 24 (day 4), dorsal aortic flow velocities were measured with a 20-MHz pulsed Doppler velocity meter, in normal and retinoic-acid-treated embryos. Flow velocity waveforms were assessed both before and after the administration of epinephrine (5 or 10 microg). RESULTS: Epinephrine caused a significant increase (p < 0.05) in heart rate, peak and mean velocities, peak acceleration, peak and mean blood flows, stroke volume and dorsal aortic area of both stage 20 and stage 24 normal and retinoic-acid-treated chick embryos. However, before epinephrine administration, stage 24 retinoic-acid-treated embryos displayed a significantly lesser increase in all outcome variables with the exception of dorsal aortic area. This was even observed after epinephrine administration. The effect of retinoic acid on cardiac output could not be compensated by epinephrine application. CONCLUSION: Epinephrine affects hemodynamics in both normal embryos and retinoic-acid-treated embryos prior to sympathetic innervation. A significant difference in hemodynamics exists between stage 24 normal and retinoic-acid-treated embryos. The underlying mechanism for the observed hemodynamic changes will need to be investigated. |
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Authors:
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Jeanne Margot Kroese; Monique L A Broekhuizen; Rob E Poelmann; Paul G H Mulder; Juriy W Wladimiroff |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 19 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2004 Sep-Oct |
Date Detail:
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Created Date: 2004-08-12 Completed Date: 2005-01-31 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 431-9 Citation Subset: IM |
Copyright Information:
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Copyright 2004 S. Karger AG, Basel |
Affiliation:
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Department of Obstetrics and Gynecology, Academic Hospital Rotterdam, Erasmus University, Rotterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects Cardiac Output / drug effects Chick Embryo Epinephrine / pharmacology* Heart / drug effects*, embryology, innervation, physiology* Heart Conduction System / embryology Heart Rate / drug effects Hemodynamics / drug effects* Stroke Volume / drug effects Sympathetic Nervous System / embryology Time Factors Tretinoin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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302-79-4/Tretinoin; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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