Document Detail

Epinephrine affects hemodynamics of noninnervated normal and all-trans retinoic acid-treated embryonic chick hearts.
MedLine Citation:
PMID:  15305100     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the acute effect of epinephrine on hemodynamics of noninnervated normal and retinoic-acid-treated embryos. DESIGN: Prospective interventional study design. METHODS: A total of 190 stage 15 (50-55 h of incubation) chick embryos were randomly treated with 1 microg all-trans retinoic acid and reincubated. At stage 20 (day 3) and stage 24 (day 4), dorsal aortic flow velocities were measured with a 20-MHz pulsed Doppler velocity meter, in normal and retinoic-acid-treated embryos. Flow velocity waveforms were assessed both before and after the administration of epinephrine (5 or 10 microg). RESULTS: Epinephrine caused a significant increase (p < 0.05) in heart rate, peak and mean velocities, peak acceleration, peak and mean blood flows, stroke volume and dorsal aortic area of both stage 20 and stage 24 normal and retinoic-acid-treated chick embryos. However, before epinephrine administration, stage 24 retinoic-acid-treated embryos displayed a significantly lesser increase in all outcome variables with the exception of dorsal aortic area. This was even observed after epinephrine administration. The effect of retinoic acid on cardiac output could not be compensated by epinephrine application. CONCLUSION: Epinephrine affects hemodynamics in both normal embryos and retinoic-acid-treated embryos prior to sympathetic innervation. A significant difference in hemodynamics exists between stage 24 normal and retinoic-acid-treated embryos. The underlying mechanism for the observed hemodynamic changes will need to be investigated.
Jeanne Margot Kroese; Monique L A Broekhuizen; Rob E Poelmann; Paul G H Mulder; Juriy W Wladimiroff
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  19     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    2004 Sep-Oct
Date Detail:
Created Date:  2004-08-12     Completed Date:  2005-01-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  431-9     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Department of Obstetrics and Gynecology, Academic Hospital Rotterdam, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Blood Flow Velocity / drug effects
Cardiac Output / drug effects
Chick Embryo
Epinephrine / pharmacology*
Heart / drug effects*,  embryology,  innervation,  physiology*
Heart Conduction System / embryology
Heart Rate / drug effects
Hemodynamics / drug effects*
Stroke Volume / drug effects
Sympathetic Nervous System / embryology
Time Factors
Tretinoin / pharmacology*
Reg. No./Substance:
302-79-4/Tretinoin; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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