Document Detail

Epinephrine modulates BCAM/Lu and ICAM-4 expression on the sickle cell trait red blood cell membrane.
MedLine Citation:
PMID:  22404936     Owner:  NLM     Status:  MEDLINE    
Collapse and sudden death in physical training are the most serious complications of sickle cell trait (SCT). There is evidence that erythrocytes in SCT patients aggregate during strenuous exercise, likely because of adhesive interactions with the extracellular matrix (ECM) and endothelial cells, and because of their irregular viscoelastic properties. This results in inflammation, blood flow impairment, and vaso-occlusive events. However, the exact role of stress conditions and how they lead to these complications is virtually unknown. Using single-molecule atomic force microscopy experiments, we found that epinephrine, a hormone that is secreted under stressful conditions, increases both the frequency and strength of adhesion events between basal cell adhesion molecule (BCAM/Lu) and ECM laminin, and between intercellular adhesion molecule-4 (ICAM-4) and endothelial α(v)β(3), compared with nonstimulated SCT erythrocytes. Increases in adhesion frequency provide significant evidence of the role of epinephrine in BCAM/Lu-laminin and ICAM-4-α(v)β(3) bonding, and suggest mechanisms of vaso-occlusion during physical exertion in SCT.
Jamie L Maciaszek; Biree Andemariam; Greg Huber; George Lykotrafitis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-06
Journal Detail:
Title:  Biophysical journal     Volume:  102     ISSN:  1542-0086     ISO Abbreviation:  Biophys. J.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-07-05     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1137-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Biophysical Society. Published by Elsevier Inc. All rights reserved.
Department of Mechanical Engineering, University of Connecticut, Storrs, Connecticut, USA.
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MeSH Terms
Cell Adhesion / drug effects
Cell Adhesion Molecules / metabolism*
Epinephrine / pharmacology*
Erythrocyte Membrane / drug effects*,  metabolism
Gene Expression Regulation / drug effects*
Integrin alphaVbeta3 / metabolism
Laminin / metabolism
Lutheran Blood-Group System / metabolism*
Sickle Cell Trait / blood*,  metabolism
Reg. No./Substance:
0/BCAM protein, human; 0/Cell Adhesion Molecules; 0/ICAM4 protein, human; 0/Integrin alphaVbeta3; 0/Laminin; 0/Lutheran Blood-Group System; 51-43-4/Epinephrine

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