| Epimerization Free Synthesis of O-Acyl Isodipeptides Employing COMU. | |
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MedLine Citation:
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PMID: 22462499 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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O-Acyl isodipeptides are prepared by coupling Boc-Ser/Thr-OBzl with Fmoc-Xaa-OH employing COMU, well known third generation peptide coupling agent. The reaction proceeds with high yield and the chemical homogeneity of the synthesized molecules were established via chiral HPLC analyses. The O-acyl isodipeptide units play crucial role in the success of ' click peptide' protocol employed for assembling ' difficult sequence' peptides. |
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Authors:
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M Samarasimhareddy; Hosahalli P Hemantha; Kuppanna Ananda; Vommina V Sureshbabu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Protein and peptide letters Volume: 19 ISSN: 1875-5305 ISO Abbreviation: Protein Pept. Lett. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441434 Medline TA: Protein Pept Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 406-10 Citation Subset: IM |
Affiliation:
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Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B. R. Ambedkar Veedhi, Bangalore -560 001, India. sureshbabuvommina@rediffmail.com; hariccb@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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