| Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy) | |
| | |
MedLine Citation:
|
PMID: 9758264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects. STUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females. RESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth. CONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (> or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (<1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures. |
| | |
Authors:
|
E Eros; P Géher; B Gömör; A E Czeizel |
Related Documents
:
|
20838574 - Folic acid supplementation stimulates notch signaling and cell proliferation in embryon... 97234 - Adjuvant activity of synthetic 6-o-"mycoloyl"-n-acetylmuramyl-l-alanyl-d-isoglutamine a... 19757214 - Folic acid supplementation for the prevention of recurrence of colorectal adenomas: met... 15151734 - Risk of fetal exposure to folic acid antagonists. 16279764 - 7-(1,1-dimethylethyl)-6-(2-ethyl-2h-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4... 16557994 - Comparison of the effects of a synthetic polyribonucleotide with the effects of endotox... |
Publication Detail:
|
Type: Case Reports; Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 80 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 1998 Sep |
Date Detail:
|
Created Date: 1998-12-03 Completed Date: 1998-12-03 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 75-8 Citation Subset: IM |
Affiliation:
|
Department of Human Genetics and Teratology, National Institute of Public Health - WHO Collaborating Centre for the Community Control of Hereditary Diseases, Budapest, Hungary. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortion, Spontaneous Anticonvulsants / administration & dosage, therapeutic use Dietary Supplements Double-Blind Method Drug Interactions Epilepsy / chemically induced*, drug therapy Female Folic Acid / administration & dosage, adverse effects* Humans Lupus Erythematosus, Systemic / chemically induced*, immunology Pregnancy Pregnancy Complications* Vitamins / administration & dosage |
| Chemical | |
Reg. No./Substance:
|
0/Anticonvulsants; 0/Vitamins; 59-30-3/Folic Acid |
| Comments/Corrections | |
Comment In:
|
Eur J Obstet Gynecol Reprod Biol. 2000 Feb;88(2):217-9
[PMID:
10690685
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Malignant fibrous histiocytoma of the stomach during pregnancy: a case report.
Next Document: Within-subject variability of differences between conventional and automated blood pressure measurem...