| Epileptiform electroencephalogram during mask induction of anesthesia with sevoflurane. | |
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MedLine Citation:
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PMID: 10598599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sevoflurane is suggested as a suitable anesthetic agent for mask induction in adults. The authors recently found that hyperventilation during sevoflurane-nitrous oxide-oxygen mask induction is associated with cardiovascular hyperdynamic response. We tested the hypothesis that the hyperdynamic response can be explained by electroencephalography (EEG) findings. METHODS: Thirty women were randomly allocated to receive sevoflurane-nitrous oxygen-oxygen mask induction using a single-breath method, followed by either spontaneous breathing (n = 15) or controlled hyperventilation (n = 15) for 6 min. EEG was recorded. Blood pressure and heart rate were recorded at 1-min intervals. RESULTS: Epileptiform EEG activity (spikes or polyspikes) was seen in all patients with controlled hyperventilation, and in seven patients with spontaneous breathing (P < 0.01). Jerking movements were seen in three patients with controlled hyperventilation. In the controlled hyperventilation group, heart rate increased 54% from baseline at 4 min after induction (P < 0.001). Mean arterial pressure increased 17% (P < 0.05), peaking at 3 min. In the spontaneous breathing group, heart rate showed no change, and mean arterial pressure decreased by 14% (P < 0.01) at 6 min. Heart rate and mean arterial pressure differed significantly between the groups from 2 min after beginning of the induction to the end of the trial. An increase in heart rate of more than 30% from baseline always was associated with epileptiform EEG activity. CONCLUSIONS: Sevoflurane mask induction elicits epileptiform EEG patterns. These are associated with an increase in heart rate in patients with controlled hyperventilation and also during spontaneous breathing of sevoflurane. |
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Authors:
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A Yli-Hankala; A Vakkuri; M Särkelä; L Lindgren; K Korttila; V Jäntti |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesiology Volume: 91 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1999 Dec |
Date Detail:
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Created Date: 1999-12-30 Completed Date: 1999-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1596-603 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland. arvi.yli-hankala@huch.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthetics, Inhalation / adverse effects* Blood Gas Analysis Blood Pressure / drug effects Double-Blind Method Electroencephalography* Epilepsy / chemically induced*, physiopathology Female Heart Rate / drug effects Humans Laryngeal Masks* Male Methyl Ethers / adverse effects* Preanesthetic Medication |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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