Document Detail

Epileptiform discharges augmented during sleep: is it a trait with diverse clinical presentation according to age of expression?
MedLine Citation:
PMID:  19910161     Owner:  NLM     Status:  MEDLINE    
Sleep has long been viewed as a negative phenomenon; however, it is now clear that it is a period of intense brain activity involving higher cortical functions. Overall, sleep affects every aspect of a child's development, particularly higher cognitive functions. The seizure threshold is often affected by changes in the level of arousal, and many interictal EEG abnormalities are activated by sleep. Epileptiform discharges augmented during sleep are described in number of epileptic syndromes characterized by infrequent clinical seizures but significant cognitive deterioration, the prototype of which is the syndrome of continuous spike-wave discharges during sleep (CSWS). In this article the conditions sharing the same EEG feature of paroxysmal epileptiform discharges augmented during sleep and their overlap will be highlighted arguing whether these disorders may be clinical presentations of same trait when expressed at different stages of brain maturity, as well as the controversies in definition and management of cases without clinical seizures.
Hanan M El Shakankiry
Publication Detail:
Type:  Journal Article; Review     Date:  2009-11-11
Journal Detail:
Title:  Epilepsy research     Volume:  89     ISSN:  1872-6844     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  113-20     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier B.V. All rights reserved.
Pediatric Neurology Division - Pediatric Department, King Fahd University Hospital of King Faisal University - Al Khobar, KSA, P.O. Box: 40284, Zip Code: 31952 - Al Khobar, Saudi Arabia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Brain / physiopathology*
Epilepsy / physiopathology*
Sleep / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Echocardiographic Features of Double-Outlet Right Atrium and Straddling Tricuspid Valve with Intact ...
Next Document:  Antimicrobial treatment and clinical outcome for infections with carbapenem- and multiply-resistant ...