| Epileptiform asymetries and treatment response in juvenile myoclonic epilepsy. | |
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MedLine Citation:
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PMID: 21059546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Epileptiform electroencephalogram (EEG) asymmetries are not uncommon in juvenile myoclonic epilepsy (JME) and can contribute to the misdiagnosis of this syndrome. The objective of this study is to further characterize patients with focal or asymmetric epileptiform electroencephalographic abnormalities and more specifically in terms of response to treatment. Controversial data exists in the literature concerning this issue. METHODS: We retrospectively reviewed clinical and EEG data of a group of consecutive JME patients followed at our Epilepsy Service. The first EEG available for each patient was reviewed blindly by two independent electroencephalographers. RESULTS: Twenty-eight patients with JME were identified: 11 (39.3%) were resistant to at least one appropriate anti-epileptic drug (AED), including valproate, lamotrigine, topiramate or levetiracetam. All patients except two had generalized epileptiform abnormalities. Overall, EEG asymmetries were detected in 57.1% of the cases. The proportion of EEG asymmetries between AED-sensitive group (52.9%) and AED-resistant group (63.5%) did not reach statistical significance. Concordance between examiners for identification of EEG asymmetries was good. Analysis of patients with and without asymmetries showed no statistically significant differences in comparisons of age, family history of seizure, presence of polyspike and slow wave, photosensitivity and timing of EEG related to the onset of treatment. CONCLUSION: Asymmetric electroencephalographic abnormalities are frequent in patients with JME. These features should not be misinterpreted as being indicative of partial epilepsy. In our group, asymmetries were not associated with resistance to treatment. |
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Authors:
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Karine Létourneau; Cécile Cieuta-Walti; Charles Deacon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 37 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-09 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: Canada |
Other Details:
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Languages: eng Pagination: 826-30 Citation Subset: IM |
Affiliation:
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Department of Neurology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Québec, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anticonvulsants / therapeutic use* Electroencephalography / methods Female Humans Magnetic Resonance Imaging Male Middle Aged Myoclonic Epilepsy, Juvenile / diagnosis, physiopathology*, therapy* Retrospective Studies Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
| Comments/Corrections | |
Comment In:
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Can J Neurol Sci. 2010 Nov;37(6):721-2
[PMID:
21059532
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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