| Epileptic spasms in clusters without hypsarrhythmia in infancy. | |
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MedLine Citation:
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PMID: 12875954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spasms are defined as epileptic seizures characterized by brief axial contraction, in flexion, extension or mixed, symmetric or asymmetric, lasting from a fraction of a second to 1-2s, and are associated with a slow-wave transient or sharp and slow-wave complex, followed or not by voltage attenuation. Epileptic spasms usually appear in clusters and are age-dependent. This type of epileptic spasms associated with the particular EEG pattern, hypsar rhythmia, constitutes the basis for the diagnosis of West syndrome. The question is, how to nosologically define those patients who clearly present epileptic spasms in clusters without modified or typical hypsarrhythmia and with or without focal paroxysmal discharges on the interictal EEG. In the present series, the four patients show that epileptic spasms in clusters may occur in infancy, without hypsarrhythmia. They all presented the following features: normal neuropsychological development before onset of epileptic spasms, clusters of epileptic spasms, focal clinical and/or EEG abnormalities, normal neuroradiological imaging, neurometabolic investigations and karyotypes. In three of the patients, seizures were refractory to AEDs. Epileptic spasms in clusters without hypsarrhythmia that start in the first year of life represent a subtype of infantile spasms that generally are refractory to AEDs. It is not yet clear whether it should be considered as a variant of West syndrome or not [Published with Video sequence]. |
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Authors:
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Roberto Horacio Caraballo; Natalio Fejerman; Bernardo Dalla Bernardina; Victor Ruggieri; Ricardo Cersósimo; Carlos Medina; Juan Pociecha |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Epileptic disorders : international epilepsy journal with videotape Volume: 5 ISSN: 1294-9361 ISO Abbreviation: Epileptic Disord Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-07-23 Completed Date: 2003-12-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100891853 Medline TA: Epileptic Disord Country: France |
Other Details:
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Languages: eng Pagination: 109-13 Citation Subset: IM |
Affiliation:
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Servicio de Neurología, Hospital de Ninos "Prof. Dr. Juan P. Garrahan", Buenos Aires, 2, Argentina. rcaraballo@janssen.com.ar |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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therapeutic use Brain Damage, Chronic / diagnosis, physiopathology Child Child, Preschool Dominance, Cerebral / physiology Drug Therapy, Combination Electroencephalography* Female Follow-Up Studies Frontal Lobe / physiopathology Humans Infant Infant, Newborn Mental Retardation / diagnosis, physiopathology Recurrence Spasms, Infantile / classification, diagnosis*, drug therapy, physiopathology Temporal Lobe / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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