Document Detail


Epileptic seizures induced by dexmedetomidine in a neonate.
MedLine Citation:
PMID:  22727734     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Dexmedetomidine hydrochloride, a highly selective 2-adrenoceptoragonist, is used in combination with local anesthetics for sedation and analgesia. It is known to be efficacious in adult patients and is enthusiastically expected to be successful for sedation in neonates. Patient: The present case report details a term infant who was sedated by dexmedetomidine during artificial ventilation. He underwent electroencephalograms that confirmed epileptic seizures and non-epileptic abnormal movements. Twelve hours after the discontinuation of dexmedetomidine, both symptoms gradually disappeared without the use of any antiepileptic medication. After then, he had achieved normal development, with no obvious neurological abnormalities. Conclusion: Dexmedetomidine acts throughout the central nervous system and leads to a reduction in the anticonvulsant activity of the locus coeruleus. This case suggests potential adverse effects of dexmedetomidine in terms of inducing both epileptic seizures and non-epileptic movements in neonates.
Authors:
Tetsuo Kubota; Tatsuya Fukasawa; Erina Kitamura; Miyuki Magota; Yuichi Kato; Jun Natsume; Akihisa Okumura
Related Documents :
9972534 - Iga nephropathy and pregnancy.
10379504 - Massive fetomaternal hemorrhage: how long should children with good evolution be contro...
673554 - Early increase in intracranial pressure in preterm infants.
3491894 - Hemorrhagic complications during extracorporeal membrane oxygenation: prevention and tr...
16583974 - Lower respiratory tract infection in infancy in relation to feeding pattern.
12673264 - Fetal macrosomia (> or =4500 g): perinatal outcome of 231 cases according to the mode o...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-21
Journal Detail:
Title:  Brain & development     Volume:  -     ISSN:  1872-7131     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
Affiliation:
Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Efficacy and Safety of Sorafenib in Patients with Advanced Hepatocellular Carcinoma: Subanalyses of ...
Next Document:  Kinematic and electromyographic analyses of normal and device-assisted sit-to-stand transfers.