Document Detail

Epileptic seizures in a descendant of Dom Pedro I.
MedLine Citation:
PMID:  20464309     Owner:  NLM     Status:  MEDLINE    
Intrauterine seizure is a rare event. Genetic predisposition and trauma are possible risk factors. OBJECTIVE: To review and comment on the historical description of intrauterine events of a bastard daughter of Dom Pedro I (Maria Isabel Alcântara Brasileira - 1830-1896). METHOD: Review of historical facts about the health of Dom Pedro I's daughter according to primary and secondary historical data. RESULTS: According to historical accounts, Dom Pedro I's daughter suffered trauma during the intrauterine period that provoked intrauterine seizures. At the age of eight years, she developed self-limited and benign generalized epilepsy. Like her father, she had mood problems and also learning difficulties. CONCLUSION: Dona Maria Isabel's own report does not shown sufficient evidence to support the diagnosis of post-traumatic intrauterine seizures. Nevertheless, her family history suggests a genetic basis for her epilepsy.
Marleide da Mota Gomes; Heber de Souza Maia Filho
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Publication Detail:
Type:  Biography; Historical Article; Journal Article; Portraits    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  68     ISSN:  1678-4227     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-13     Completed Date:  2010-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  317-9     Citation Subset:  IM    
Epilepsy Program, Instituto de Neurologia Deolindo Couto, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
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MeSH Terms
Epilepsy / genetics,  history*
Fetal Diseases / history
Genetic Predisposition to Disease / history
History, 19th Century
Personal Name Subject
Personal Name Subject:
Alcântara Brasileira Maria Isabel

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