Document Detail


Epileptic seizure-induced structural and functional changes in rat femur and tibia bone tissues: a Fourier transform infrared imaging study.
MedLine Citation:
PMID:  23887385     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ABSTRACT. The disease- and drug-related bone disorders are rapidly increasing in the population. It is previously reported that anti-epileptic drugs (AEDs) may cause osteopenia, osteoporosis, and fractures in epilepsy patients. However, it cannot be determined whether the bone disorders in epileptic patients are due to AED therapy and/or to epilepsy and epileptic seizures. There is no study in the literature which investigates the sole effects of epilepsy and epileptic seizures on bone tissues. The current study provides the first report on determination of the possible effects of epilepsy and epileptic seizures on long bone tissues. Wistar Albino Glaxo/Rijswijk rats, which are accepted as genetic rat models for human absence epilepsy, were compared with the healthy Wistar rats to get information about the sole effects of epilepsy and epileptic seizures on bones. Cortical regions of tibia and femur bones were studied by Fourier transform infrared microspectroscopy (FTIRM). According to FTIRM parameters, variation on bone mineral and matrix composition, including decreased mineral content, decreased collagen cross-links, increased carbonate substitution, and larger crystals in epileptic group compared to the healthy one, show severe effects of epilepsy and seizures on bone tissues for the first time.
Authors:
Sebnem Garip; Deniz Sahin; Feride Severcan
Related Documents :
24718005 - Giant cell tumour of proximal radius in a 48 years old lady.
23638215 - Overexpression of integrin a2 promotes osteogenic differentiation of hbmscs from senile...
23580825 - Familial multiple exostosis arising from bones of enchondral as well as membranous (in ...
23683605 - Compositional and material properties of rat bone after bisphosphonate and/or strontium...
1090405 - Deformities of the midface resulting from malunited orbital and naso-orbital fractures.
20730585 - Bone mineral density in the femoral neck increases after hip resurfacing: a cohort with...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  18     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111409     Citation Subset:  IM    
Affiliation:
Middle East Technical University, Department of Biochemistry, 06531 Ankara, TurkeybIstanbul Kemerburgaz University, Department of Medical Biochemistry, Faculty of Medicine, 34217 Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dependence of light scattering profile in tissue on blood vessel diameter and distribution: a comput...
Next Document:  Associations Between Female Reproductive Traits and Polychlorinated Biphenyl Sediment Concentrations...