Document Detail

Epileptic seizure-induced structural and functional changes in rat femur and tibia bone tissues: a Fourier transform infrared imaging study.
MedLine Citation:
PMID:  23887385     Owner:  NLM     Status:  MEDLINE    
The disease- and drug-related bone disorders are rapidly increasing in the population. It is previously reported that anti-epileptic drugs (AEDs) may cause osteopenia, osteoporosis, and fractures in epilepsy patients. However, it cannot be determined whether the bone disorders in epileptic patients are due to AED therapy and/or to epilepsy and epileptic seizures. There is no study in the literature which investigates the sole effects of epilepsy and epileptic seizures on bone tissues. The current study provides the first report on determination of the possible effects of epilepsy and epileptic seizures on long bone tissues. Wistar Albino Glaxo/Rijswijk rats, which are accepted as genetic rat models for human absence epilepsy, were compared with the healthy Wistar rats to get information about the sole effects of epilepsy and epileptic seizures on bones. Cortical regions of tibia and femur bones were studied by Fourier transform infrared microspectroscopy (FTIRM). According to FTIRM parameters, variation on bone mineral and matrix composition, including decreased mineral content, decreased collagen cross-links, increased carbonate substitution, and larger crystals in epileptic group compared to the healthy one, show severe effects of epilepsy and seizures on bone tissues for the first time.
Sebnem Garip; Deniz Sahin; Feride Severcan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  18     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-07-26     Completed Date:  2014-02-04     Revised Date:  2014-07-07    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111409     Citation Subset:  IM    
Copyright Information:
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
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MeSH Terms
Analysis of Variance
Carbonates / analysis,  chemistry
Collagen / analysis,  chemistry
Disease Models, Animal
Epilepsy / pathology*
Femur / chemistry*,  pathology*
Rats, Wistar
Spectroscopy, Fourier Transform Infrared / methods*
Tibia / chemistry*,  pathology*
Reg. No./Substance:
0/Carbonates; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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