Document Detail


Epilepsy and common comorbidities: improving the outpatient epilepsy encounter.
MedLine Citation:
PMID:  16120491     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epilepsy is a chronic disorder that has been associated with other specific health problems. Evidence from recent clinical and basic investigations indicates that aspects of cerebral dysfunction associated with a lowered seizure threshold may also predispose toward other disorders such as depression, cognitive impairment, sleep disorders, and migraine. Similarly, certain types of brain injury may also increase the risk of adverse antiepileptic drug (AED) effects. For example, a history of febrile seizures is associated with a three fold increase in the occurrence of negative psychiatric effects of two newer AEDs. Poor fitness and obesity are also reported at higher rates in epilepsy. Some comorbid conditions in epilepsy, such a depression and anxiety, may have a greater influence on subjective health status than does seizure rate. Management strategies employed in the outpatient clinic to maximize overall health outcomes should include screening and treatment for the commonly coexistent conditions in persons with epilepsy.
Authors:
Frank G Gilliam; Anil Mendiratta; Alison M Pack; Carl W Bazil
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Epileptic disorders : international epilepsy journal with videotape     Volume:  7 Suppl 1     ISSN:  1294-9361     ISO Abbreviation:  Epileptic Disord     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-25     Completed Date:  2007-05-17     Revised Date:  2008-09-16    
Medline Journal Info:
Nlm Unique ID:  100891853     Medline TA:  Epileptic Disord     Country:  France    
Other Details:
Languages:  eng     Pagination:  S27-33     Citation Subset:  IM    
Affiliation:
Department of Neurology, Neurological Institute, Columbia University, New York, NY 10032, USA. fgilliam@neuro.columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Comorbidity
Depression / epidemiology*
Epilepsy / epidemiology*
Humans
Migraine Disorders / epidemiology*
Physical Fitness / physiology
Sleep Disorders / epidemiology*
Grant Support
ID/Acronym/Agency:
NS01794/NS/NINDS NIH HHS; NS047551/NS/NINDS NIH HHS; NS40808/NS/NINDS NIH HHS
Comments/Corrections
Erratum In:
Epileptic Disord. 2008 Jun;10(2):191

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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