| Epilepsy Treatment in Rett Syndrome. | |
| | |
MedLine Citation:
|
PMID: 21636780 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Rett syndrome is a neurodevelopmental disorder predominately affecting females. The majority of patients have epilepsy in the early stages of the disease. This study evaluates the clinical course of epilepsy and the effect of antiepileptic drug treatment in Rett syndrome using retrospective data analysis. Epilepsy was present in 16 of 19 (84%) patients with Rett syndrome in this series. The mean age of seizure onset was 4 years. Remission of seizures was achieved after the first monotherapy in 56% and after the second monotherapy in 18.5% of patients. Valproate, lamotrigine, and carbamazepine were the drugs used most frequently as monotherapy. Valproate monotherapy was highly effective as 75% of treated patients achieved seizure remission. Monotherapy with lamotrigine or carbamazepine was effective in half of the treated patients. There was a clear tendency toward seizure remission after the age of 15 years. |
| | |
Authors:
|
Natalija Krajnc; Neza Zupancic; Jasna Orazem |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-2 |
Journal Detail:
|
Title: Journal of child neurology Volume: - ISSN: 1708-8283 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University Children's Hospital, Department of Child, Adolescent and Developmental Neurology, Ljubljana, Slovenia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Change in Gross Motor Abilities of Girls and Women With Rett Syndrome Over a 3- to 4-Year Period.
Next Document: Abnormal Brain Protein Synthesis in Language Areas of Children With Pervasive Developmental Disorder...