Document Detail


Epigenomics of T cell activation, differentiation, and memory.
MedLine Citation:
PMID:  20226645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Activation of T cells is an essential step in the immunological response to infection. Although activation of naïve T cells results in proliferation and slow differentiation into cytokine-producing effector cells, antigen engagement with memory cells leads to cytokine production immediately. Even though the cell surface signaling events are similar in both the cases, the outcome is different, suggesting that distinct regulatory mechanisms may exist downstream of the activation signals. Recent advances in the understanding of global epigenetic patterns in T cells have resulted in the appreciation of the role of epigenetic mechanisms in processes such as activation and differentiation. In this review we discuss recent data suggesting that naïve T cell activation, differentiation, and lineage commitment result in epigenetic changes and a fine balance between different histone modifications is required. On the other hand, memory T cells are poised and do not require epigenetic changes for short-term activation.
Authors:
Suresh Cuddapah; Artem Barski; Keji Zhao
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review     Date:  2010-03-11
Journal Detail:
Title:  Current opinion in immunology     Volume:  22     ISSN:  1879-0372     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-10-04     Revised Date:  2013-04-25    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  341-7     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Affiliation:
Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. cuddapas@nhlbi.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / genetics
Epigenesis, Genetic*
Humans
Immunologic Memory / genetics*
Lymphocyte Activation* / genetics
Mice
T-Lymphocytes / immunology*
Grant Support
ID/Acronym/Agency:
1K22HL098691/HL/NHLBI NIH HHS; K22 HL098691/HL/NHLBI NIH HHS; Z01 HL005801-05/HL/NHLBI NIH HHS
Comments/Corrections

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