Document Detail

Epigenomic regulation of bile acid metabolism: emerging role of transcriptional cofactors.
MedLine Citation:
PMID:  22579755     Owner:  NLM     Status:  MEDLINE    
The traditional role of bile acids is to simply facilitate absorption and digestion of lipid nutrients, but bile acids also act as endocrine signaling molecules that activate nuclear and membrane receptors to control integrative metabolism and energy balance. The mechanisms by which bile acid signals are integrated to regulate target genes are, however, largely unknown. Recently emerging evidence has shown that transcriptional cofactors sense metabolic changes and modulate gene transcription by mediating reversible epigenomic post-translational modifications (PTMs) of histones and chromatin remodeling. Importantly, targeting these epigenomic changes has been a successful approach for treating human diseases, especially cancer. Here, we review emerging roles of transcriptional cofactors in the epigenomic regulation of liver metabolism, especially focusing on bile acid metabolism. Targeting PTMs of histones and chromatin remodelers, together with the bile acid-activated receptors, may provide new therapeutic options for bile acid-related disease, such as cholestasis, obesity, diabetes, and entero-hepatic cancers.
Zachary Smith; Daniel Ryerson; Jongsook Kim Kemper
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-05-09
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  368     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-20     Completed Date:  2013-09-10     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  59-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Bile Acids and Salts / metabolism*
DNA-Binding Proteins / physiology
Epigenesis, Genetic*
Histone Deacetylases / physiology
Lipid Metabolism
Liver / metabolism
Protein Processing, Post-Translational
Receptors, Cytoplasmic and Nuclear / physiology
Transcription Factors / physiology*
Grant Support
Reg. No./Substance:
0/Bile Acids and Salts; 0/DNA-Binding Proteins; 0/MLL3 protein, human; 0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; 0/nuclear receptor subfamily 0, group B, member 2; EC Deacetylases

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