Document Detail


Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero.
MedLine Citation:
PMID:  23354385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Targeting epigenetic mechanisms during initial learning or memory retrieval can lead to persistent memory. Retrieval induces plasticity that may result in reconsolidation of the original memory, in which critical molecular events are needed to stabilize the memory, or extinction, in which new learning during the retrieval trial creates an additional memory that reflects the changed environmental contingencies. A canonical feature of extinction is that the original response is temporarily suppressed, but returns under various conditions. These characteristics have defined whether a given manipulation alters extinction (when persistence does not occur) or reconsolidation (when persistence does occur). A problem arises with these behavioral definitions when considering the potential for persistent memory of extinction. Recent studies have found that epigenetic modulation of memory processes leads to surprisingly robust and persistent extinction. We discuss evidence from behavioral epigenetic approaches that forces a re-evaluation of widely used behavioral definitions of extinction and reconsolidation.
Authors:
K Matthew Lattal; Marcelo A Wood
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-28
Journal Detail:
Title:  Nature neuroscience     Volume:  16     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-03-22     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  124-9     Citation Subset:  IM    
Affiliation:
Oregon Health & Science University, Portland, Oregon, USA. lattalm@ohsu.edu
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MeSH Terms
Descriptor/Qualifier:
Epigenesis, Genetic / physiology*
Epigenomics*
Extinction, Psychological / physiology
Humans
Memory, Long-Term / physiology*
Grant Support
ID/Acronym/Agency:
DA018165/DA/NIDA NIH HHS; DA025922/DA/NIDA NIH HHS; DA031989/DA/NIDA NIH HHS; MH077111/MH/NIMH NIH HHS; MH081004/MH/NIMH NIH HHS; R01 DA025922/DA/NIDA NIH HHS; R01 MH081004/MH/NIMH NIH HHS; R21 DA031989/DA/NIDA NIH HHS
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