Document Detail


Epigenetics and microRNAs in preeclampsia.
MedLine Citation:
PMID:  22468840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Strong evidence suggests a potential link among epigenetics, microRNAs (miRNAs), and pregnancy complications. Much research still needs to be carried out to determine whether epigenetic factors are predictive in the pathogenesis of preeclampsia (PE), a life-threatening disease during pregnancy. Recently, the importance of maternal epigenetic features, including DNA methylation, histone modifications, epigenetically regulated miRNA, and the effect of imprinted or non-imprinted genes on trophoblast growth, invasion, as well as fetal development and hypertension in pregnancy, has been demonstrated in a series of articles. This article discusses the current evidence of this complicated network of miRNA and epigenetic factors as potential mechanisms that may underlie the theories of disease for PE. Translating these basic epigenetic findings to clinical practice could potentially serve as prognostic biomarkers for diagnosis in its early stages and could help in the development of prophylactic strategies.
Authors:
Mahua Choudhury; Jacob E Friedman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-02
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  34     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-18     Completed Date:  2012-12-03     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  334-41     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA. mahua.choudhury@ucdenver.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA Methylation / genetics
Epigenesis, Genetic*
Female
Histones / metabolism
Humans
MicroRNAs / genetics*,  metabolism
Pre-Eclampsia / etiology,  genetics*
Pregnancy
Grant Support
ID/Acronym/Agency:
DK59767/DK/NIDDK NIH HHS; P30-DK48520/DK/NIDDK NIH HHS; R24 DK090964/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Histones; 0/MicroRNAs
Comments/Corrections

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