| Epigenetics and microRNAs in preeclampsia. | |
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MedLine Citation:
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PMID: 22468840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Strong evidence suggests a potential link among epigenetics, microRNAs (miRNAs), and pregnancy complications. Much research still needs to be carried out to determine whether epigenetic factors are predictive in the pathogenesis of preeclampsia (PE), a life-threatening disease during pregnancy. Recently, the importance of maternal epigenetic features, including DNA methylation, histone modifications, epigenetically regulated miRNA, and the effect of imprinted or non-imprinted genes on trophoblast growth, invasion, as well as fetal development and hypertension in pregnancy, has been demonstrated in a series of articles. This article discusses the current evidence of this complicated network of miRNA and epigenetic factors as potential mechanisms that may underlie the theories of disease for PE. Translating these basic epigenetic findings to clinical practice could potentially serve as prognostic biomarkers for diagnosis in its early stages and could help in the development of prophylactic strategies. |
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Authors:
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Mahua Choudhury; Jacob E Friedman |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-04-02 |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 34 ISSN: 1525-6006 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-07-18 Completed Date: 2012-12-03 Revised Date: 2013-03-12 |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 334-41 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA. mahua.choudhury@ucdenver.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA Methylation / genetics Epigenesis, Genetic* Female Histones / metabolism Humans MicroRNAs / genetics*, metabolism Pre-Eclampsia / etiology, genetics* Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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DK59767/DK/NIDDK NIH HHS; P30-DK48520/DK/NIDDK NIH HHS; R24 DK090964/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Histones; 0/MicroRNAs |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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