Document Detail


Epigenetics of drug abuse: predisposition or response.
MedLine Citation:
PMID:  22909205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Drug addiction continues to be a serious medical and social problem. Vulnerability to develop an addiction to drugs is dependent on genetic, environmental, social and biological factors. In particular, the interactions of environmental and genetic factors indicate the significance of epigenetic mechanisms, which have been found to occur in response to illicit drug use or as underlying factors in chronic substance abuse and relapse. Epigenetics is defined as the heritable and possibly reversible modifications in gene expression that do not involve alterations in the DNA sequence. This review discusses the various types of epigenetic modifications and their relevance to drug addiction to elucidate whether epigenetics is a predisposing factor, or a response to, developing an addiction to drugs of abuse.
Authors:
David A Nielsen; Amol Utrankar; Jennifer A Reyes; Daniel D Simons; Thomas R Kosten
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Pharmacogenomics     Volume:  13     ISSN:  1744-8042     ISO Abbreviation:  Pharmacogenomics     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-22     Completed Date:  2013-04-03     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  100897350     Medline TA:  Pharmacogenomics     Country:  England    
Other Details:
Languages:  eng     Pagination:  1149-60     Citation Subset:  IM    
Affiliation:
Menninger Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine & the Michael E DeBakey VA Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA. nielsen@bcm.edu
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MeSH Terms
Descriptor/Qualifier:
Behavior, Addictive / genetics
Chromatin Assembly and Disassembly / drug effects
Cocaine / administration & dosage*
DNA Methylation / drug effects
Epigenesis, Genetic*
Genetic Predisposition to Disease
Heroin / administration & dosage*
Humans
Receptors, Opioid, mu / genetics
Serotonin Plasma Membrane Transport Proteins / genetics
Substance-Related Disorders / genetics*
Grant Support
ID/Acronym/Agency:
5P50 DA018197-05/DA/NIDA NIH HHS; P50 DA018197/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/OPRM1 protein, human; 0/Receptors, Opioid, mu; 0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins; 50-36-2/Cocaine; 561-27-3/Heroin
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