| Epigenetics of autoimmune diabetes. | |
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MedLine Citation:
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PMID: 22126251 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Classical genetic studies established a link between Type 1 diabetes, a common childhood autoimmune disease and genes that encode MHC antigens and several immune-related determinants. The mechanisms by which these genes contribute to the initiation and perpetuation of Type 1 diabetes remain enigmatic. Emerging data indicate a role for epigenetic mechanisms involving hyperacetylation of histones in the differential gene expression and amelioration of autoimmune diabetes in a mouse model. In this article the implications of these and other epigenetic mechanisms including ncRNA-mediated gene regulation in the abrogation of autoimmune diabetes are discussed. Concerted efforts to decipher the epigenetics of Type 1 diabetes may provide novel perspectives on autoimmune diabetogenesis. |
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Authors:
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Sundararajan Jayaraman |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Epigenomics Volume: 3 ISSN: 1750-192X ISO Abbreviation: Epigenomics Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101519720 Medline TA: Epigenomics Country: England |
Other Details:
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Languages: eng Pagination: 639-48 Citation Subset: IM |
Affiliation:
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Deptartment of Medicine, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA. anue2468@uic.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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