Document Detail


Epigenetics and psychostimulant addiction.
MedLine Citation:
PMID:  23359110     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic drug exposure alters gene expression in the brain and produces long-term changes in neural networks that underlie compulsive drug taking and seeking. Exactly how drug-induced changes in synaptic plasticity and subsequent gene expression are translated into persistent neuroadaptations remains unclear. Emerging evidence suggests that complex drug-induced neuroadaptations in the brain are mediated by highly synchronized and dynamic patterns of gene regulation. Recently, it has become clear that epigenetic mechanisms contribute to drug-induced structural, synaptic, and behavioral plasticity by regulating expression of gene networks. Here we review how alterations in histone modifications, DNA methylation, and microRNAs regulate gene expression and contribute to psychostimulant addiction with a focus on the epigenetic mechanisms that regulate brain-derived neurotrophic factor (BDNF) expression following chronic cocaine exposure. Identifying epigenetic signatures that define psychostimulant addiction may lead to novel, efficacious treatments for drug craving and relapse.
Authors:
Heath D Schmidt; Jacqueline F McGinty; Anne E West; Ghazaleh Sadri-Vakili
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-03-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in medicine     Volume:  3     ISSN:  2157-1422     ISO Abbreviation:  Cold Spring Harb Perspect Med     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-19     Revised Date:  2014-04-11    
Medline Journal Info:
Nlm Unique ID:  101571139     Medline TA:  Cold Spring Harb Perspect Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  a012047     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylation / drug effects
Brain-Derived Neurotrophic Factor / genetics,  metabolism
Central Nervous System Stimulants*
Chromatin / chemistry,  genetics
Cocaine-Related Disorders / genetics
DNA Methylation / drug effects
Epigenomics*
Genome-Wide Association Study
Histones / metabolism
Humans
Methylation / drug effects
MicroRNAs / genetics
Substance-Related Disorders / genetics*
Transcription, Genetic / genetics
Grant Support
ID/Acronym/Agency:
DA022339/DA/NIDA NIH HHS; K01 DA030445/DA/NIDA NIH HHS; K01 DA030445/DA/NIDA NIH HHS; NS063953/NS/NINDS NIH HHS; P50-DA15369/DA/NIDA NIH HHS; R01 DA033610/DA/NIDA NIH HHS; R01-DA022202/DA/NIDA NIH HHS; R01-DA03982/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Central Nervous System Stimulants; 0/Chromatin; 0/Histones; 0/MicroRNAs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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