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Epigenetics: A New Bridge between Nutrition and Health.
MedLine Citation:
PMID:  22043447     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Nutrients can reverse or change epigenetic phenomena such as DNA methylation and histone modifications, thereby modifying the expression of critical genes associated with physiologic and pathologic processes, including embryonic development, aging, and carcinogenesis. It appears that nutrients and bioactive food components can influence epigenetic phenomena either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications, or by altering the availability of substrates necessary for those enzymatic reactions. In this regard, nutritional epigenetics has been viewed as an attractive tool to prevent pediatric developmental diseases and cancer as well as to delay aging-associated processes. In recent years, epigenetics has become an emerging issue in a broad range of diseases such as type 2 diabetes mellitus, obesity, inflammation, and neurocognitive disorders. Although the possibility of developing a treatment or discovering preventative measures of these diseases is exciting, current knowledge in nutritional epigenetics is limited, and further studies are needed to expand the available resources and better understand the use of nutrients or bioactive food components for maintaining our health and preventing diseases through modifiable epigenetic mechanisms.
Sang-Woon Choi; Simonetta Friso
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Publication Detail:
Type:  Journal Article     Date:  2010-11-16
Journal Detail:
Title:  Advances in nutrition (Bethesda, Md.)     Volume:  1     ISSN:  2156-5376     ISO Abbreviation:  Adv Nutr     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-11-01     Completed Date:  2011-11-10     Revised Date:  2012-02-08    
Medline Journal Info:
Nlm Unique ID:  101540874     Medline TA:  Adv Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-16     Citation Subset:  -    
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111.
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