| Epigenetic transitions in germ cell development and meiosis. | |
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MedLine Citation:
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PMID: 21074718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Germ cell development is controlled by unique gene expression programs and involves epigenetic reprogramming of histone modifications and DNA methylation. The central event is meiosis, during which homologous chromosomes pair and recombine, processes that involve histone alterations. At unpaired regions, chromatin is repressed by meiotic silencing. After meiosis, male germ cells undergo chromatin remodeling, including histone-to-protamine replacement. Male and female germ cells are also differentially marked by parental imprints, which contribute to sex determination in insects and mediate genomic imprinting in mammals. Here, we review epigenetic transitions during gametogenesis and discuss novel insights from animal and human studies. |
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Authors:
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Satya K Kota; Robert Feil |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Developmental cell Volume: 19 ISSN: 1878-1551 ISO Abbreviation: Dev. Cell Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-15 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120028 Medline TA: Dev Cell Country: United States |
Other Details:
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Languages: eng Pagination: 675-86 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Institute of Molecular Genetics, CNRS UMR5535 and University of Montpellier I & II, 1919 route de Mende, 34293 Montpellier, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatin / genetics, metabolism Chromatin Assembly and Disassembly DNA Methylation Epigenesis, Genetic* Gametogenesis / genetics* Gene Silencing Genomic Imprinting Germ Cells / physiology* Histone-Lysine N-Methyltransferase / metabolism Histones / metabolism Humans Meiosis / genetics* Recombination, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/Histones; EC 2.1.1.-/histone methyltransferase; EC 2.1.1.43/Histone-Lysine N-Methyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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