Document Detail


Epigenetic transitions in germ cell development and meiosis.
MedLine Citation:
PMID:  21074718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Germ cell development is controlled by unique gene expression programs and involves epigenetic reprogramming of histone modifications and DNA methylation. The central event is meiosis, during which homologous chromosomes pair and recombine, processes that involve histone alterations. At unpaired regions, chromatin is repressed by meiotic silencing. After meiosis, male germ cells undergo chromatin remodeling, including histone-to-protamine replacement. Male and female germ cells are also differentially marked by parental imprints, which contribute to sex determination in insects and mediate genomic imprinting in mammals. Here, we review epigenetic transitions during gametogenesis and discuss novel insights from animal and human studies.
Authors:
Satya K Kota; Robert Feil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Developmental cell     Volume:  19     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  675-86     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Institute of Molecular Genetics, CNRS UMR5535 and University of Montpellier I & II, 1919 route de Mende, 34293 Montpellier, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatin / genetics,  metabolism
Chromatin Assembly and Disassembly
DNA Methylation
Epigenesis, Genetic*
Gametogenesis / genetics*
Gene Silencing
Genomic Imprinting
Germ Cells / physiology*
Histone-Lysine N-Methyltransferase / metabolism
Histones / metabolism
Humans
Meiosis / genetics*
Recombination, Genetic
Chemical
Reg. No./Substance:
0/Chromatin; 0/Histones; EC 2.1.1.-/histone methyltransferase; EC 2.1.1.43/Histone-Lysine N-Methyltransferase

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