Document Detail

Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis.
MedLine Citation:
PMID:  23423526     Owner:  NLM     Status:  In-Data-Review    
Epigenetics involve heritable and acquired changes in gene transcription that occur independently of the DNA sequence. Epigenetic mechanisms constitute a hierarchic upper-level of transcriptional control through complex modifications of chromosomal components and nuclear structures. These modifications include, for example, DNA methylation or post-translational modifications of core histones; they are mediated by various chromatin-modifying enzymes; and ultimately they define the accessibility of a transcriptional complex to its target DNA. Integrating epigenetic mechanisms into the pathophysiologic concept of complex and multifactorial diseases such as atherosclerosis may significantly enhance our understanding of related mechanisms and provide promising therapeutic approaches. Although still in its infancy, intriguing scientific progress has begun to elucidate the role of epigenetic mechanisms in vascular biology, particularly in the control of smooth muscle cell phenotypes. In this review, we will summarize epigenetic pathways in smooth muscle cells, focusing on mechanisms involved in the regulation of vascular remodeling.
Hannes M Findeisen; Florian K Kahles; Dennis Bruemmer
Related Documents :
12932286 - Extracellular mitochondrial dna and oxidatively damaged dna in synovial fluid of patien...
16512776 - Transrenal dna testing: progress and perspectives.
1977686 - Prenatal diagnosis of familial amyloidotic polyneuropathy: evidence for an early expres...
20846806 - Molecular epidemiology of saccharomyces cerevisiae in an immunocompromised host unit.
1731886 - Analysis of promoter-specific repression by triple-helical dna complexes in a eukaryoti...
20580766 - Folate mediated in vitro targeting of depolymerised trimethylated chitosan having argin...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  15     ISSN:  1534-6242     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319     Citation Subset:  IM    
Department of Internal Medicine I-Cardiology, University Hospital Aachen, RWTH Aachen, Pauwelstr. 30, 52074, Aachen, Germany,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ambulatory blood pressure improves prediction of cardiovascular risk: implications for better antihy...
Next Document:  Increased homologous integration frequency in Yarrowia lipolytica strains defective in non-homologou...