Document Detail

Epigenetic regulation for the induction of meiosis.
MedLine Citation:
PMID:  17131058     Owner:  NLM     Status:  MEDLINE    
The germ cell lineage is the sole cell lineage through which genomic information is transmitted into successive generations. To this end, germ cells undergo various specific differentiation steps including meiosis, whose regulation seems to correlate closely with fundamental mechanisms that create differences between germ cells and somatic cells. In mammals, meiosis is triggered by extra-embryonic stimuli such as retinoic acid, which may induce various intracellular molecular cascades promoting meiosis. In addition, the specific epigenetic status arranged in germ cells before and after induction of meiosis, including meiosis-specific transcription control based on histone methylation by a novel histone methyltransferase Meisetz, is also critical for its proper progression.
Y Matsui; K Hayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  64     ISSN:  1420-682X     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-12     Completed Date:  2007-03-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  257-62     Citation Subset:  IM    
Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Seiryo-machi 4-1, Sendai 980-8575, Japan.
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MeSH Terms
DNA Methylation
Epigenesis, Genetic*
Histone-Lysine N-Methyltransferase / metabolism
Histones / metabolism
Meiosis / genetics*
RNA, Small Interfering / metabolism
Transcription, Genetic
Reg. No./Substance:
0/Histones; 0/RNA, Small Interfering; EC N-Methyltransferase

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