| Epigenetic regulation for the induction of meiosis. | |
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MedLine Citation:
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PMID: 17131058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The germ cell lineage is the sole cell lineage through which genomic information is transmitted into successive generations. To this end, germ cells undergo various specific differentiation steps including meiosis, whose regulation seems to correlate closely with fundamental mechanisms that create differences between germ cells and somatic cells. In mammals, meiosis is triggered by extra-embryonic stimuli such as retinoic acid, which may induce various intracellular molecular cascades promoting meiosis. In addition, the specific epigenetic status arranged in germ cells before and after induction of meiosis, including meiosis-specific transcription control based on histone methylation by a novel histone methyltransferase Meisetz, is also critical for its proper progression. |
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Authors:
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Y Matsui; K Hayashi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 64 ISSN: 1420-682X ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-12 Completed Date: 2007-03-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 257-62 Citation Subset: IM |
Affiliation:
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Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, Seiryo-machi 4-1, Sendai 980-8575, Japan. ymatsui@idac.tohoku.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA Methylation Epigenesis, Genetic* Female Histone-Lysine N-Methyltransferase / metabolism Histones / metabolism Male Meiosis / genetics* Mice RNA, Small Interfering / metabolism Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Histones; 0/RNA, Small Interfering; EC 2.1.1.43/Histone-Lysine N-Methyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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