| Epigenetic regulation in psychiatric disorders. | |
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MedLine Citation:
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PMID: 17453016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many neurological and most psychiatric disorders are not due to mutations in a single gene; rather, they involve molecular disturbances entailing multiple genes and signals that control their expression. Recent research has demonstrated that complex 'epigenetic' mechanisms, which regulate gene activity without altering the DNA code, have long-lasting effects within mature neurons. This review summarizes recent evidence for the existence of sustained epigenetic mechanisms of gene regulation in neurons that have been implicated in the regulation of complex behaviour, including abnormalities in several psychiatric disorders such as depression, drug addiction and schizophrenia. |
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Authors:
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Nadia Tsankova; William Renthal; Arvind Kumar; Eric J Nestler |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Nature reviews. Neuroscience Volume: 8 ISSN: 1471-003X ISO Abbreviation: Nat. Rev. Neurosci. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-24 Completed Date: 2007-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962781 Medline TA: Nat Rev Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 355-67 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / pathology Epigenesis, Genetic / physiology* Gene Expression Regulation / physiology* Humans Mental Disorders / genetics*, pathology, physiopathology* Models, Biological Neurons / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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