Document Detail


Epigenetic regulation of heterochromatic DNA stability.
MedLine Citation:
PMID:  18372168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this review we summarize recent studies that demonstrate the importance of epigenetic mechanisms for maintaining genome integrity, specifically with respect to repeated DNAs within heterochromatin. Potential problems that arise during replication, recombination, and repair of repeated sequences are counteracted by post-translational histone modifications and associated proteins, including the cohesins. These factors appear to ensure repeat stability by multiple mechanisms: suppressing homologous recombination, controlling the three-dimensional organization of damaged repeats to reduce the probability of aberrant recombination, and promoting the use of less problematic repair pathways. The presence of such systems may facilitate repeat and chromosome evolution, and their failure can lead to genome instability, chromosome rearrangements, and the onset of pathogenesis.
Authors:
Jamy C Peng; Gary H Karpen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2008-03-26
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  18     ISSN:  0959-437X     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-09-05     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  204-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Evolution
Cell Nucleus / genetics
DNA / genetics*
Epigenesis, Genetic / genetics*
Heterochromatin / genetics*
Humans
Tandem Repeat Sequences
Grant Support
ID/Acronym/Agency:
R01 GM061169/GM/NIGMS NIH HHS; R01 GM061169-04/GM/NIGMS NIH HHS; R01 GM066272/GM/NIGMS NIH HHS; R01HG00747/HG/NHGRI NIH HHS
Chemical
Reg. No./Substance:
0/Heterochromatin; 9007-49-2/DNA
Comments/Corrections

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