| Epigenetic regulation of heterochromatic DNA stability. | |
MedLine Citation:
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PMID: 18372168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this review we summarize recent studies that demonstrate the importance of epigenetic mechanisms for maintaining genome integrity, specifically with respect to repeated DNAs within heterochromatin. Potential problems that arise during replication, recombination, and repair of repeated sequences are counteracted by post-translational histone modifications and associated proteins, including the cohesins. These factors appear to ensure repeat stability by multiple mechanisms: suppressing homologous recombination, controlling the three-dimensional organization of damaged repeats to reduce the probability of aberrant recombination, and promoting the use of less problematic repair pathways. The presence of such systems may facilitate repeat and chromosome evolution, and their failure can lead to genome instability, chromosome rearrangements, and the onset of pathogenesis. |
Authors:
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Jamy C Peng; Gary H Karpen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2008-03-26 |
Journal Detail:
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Title: Current opinion in genetics & development Volume: 18 ISSN: 0959-437X ISO Abbreviation: Curr. Opin. Genet. Dev. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-06-03 Completed Date: 2008-09-05 Revised Date: 2014-09-16 |
Medline Journal Info:
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Nlm Unique ID: 9111375 Medline TA: Curr Opin Genet Dev Country: England |
Other Details:
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Languages: eng Pagination: 204-11 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Evolution Cell Nucleus / genetics DNA / genetics* Epigenesis, Genetic / genetics* Heterochromatin / genetics* Humans Tandem Repeat Sequences |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM061169/GM/NIGMS NIH HHS; R01 GM061169-04/GM/NIGMS NIH HHS; R01 GM066272/GM/NIGMS NIH HHS; R01HG00747/HG/NHGRI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Heterochromatin; 9007-49-2/DNA |
| Comments/Corrections | |
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